Methylprednisolone

Methylprednisolone sodium succinate is indicated to treat the following conditions: 1. Endocrine diseases Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone are the medicines of choice, however, synthetic analogues can be used in combination with mineralocorticoids; in children, it is of particular importance to supplementary administration of mineralocorticoids).

Acute adrenocortical insufficiency (hydrocortisone or cortisone are the medicines of choice; conjugation with mineralocorticoids may be necessary, particularly when using its synthetic analogues). Pre-operatively and in case of trauma or serious illness, in patients with adrenocortical insufficiency or when the adrenal reserve is doubtful: - Congenital adrenal hyperplasia; - Non-suppurative thyroiditis; - Hypercalcemia associated with cancer.

2. Rheumatic diseases Methylprednisolone is used as an adjuvant therapy for short-term administration to relieve the patient in the event of an acute episode or exacerbation of: - Post-traumatic osteoarthritis; - Osteoarthritis synovitis; - Rheumatoid arthritis including juvenile idiopathic arthritis (certain cases may require low dose maintenance therapy); - Acute and subacute bursitis; - Epicondylitis; - Acute non-specific tenosynovitis; - Acute gouty arthritis; - Psoriatic arthritis; - Ankylosing spondylitis.

Intravenous administration of SOLU-MEDROL (methylprednisolone sodium succinate) is indicated in situations in which a rapid and intense hormonal effect is required. SOLU-MEDROL (methylprednisolone sodium succinate) is indicated for: • Hypersensitivity and dermatologic conditions - Status asthmaticus - Anaphylactic reactions - Drug reactions - Contact dermatitis - Urticaria - Generalized neurodermatitis - Reactions to insect bites - Pemphigus foliaceous and vulgaris - Exfoliative dermatitis - Erythema multiforme • In anaphylactic reactions epinephrine or norepinephrine should be administered first for an immediate hemodynamic effect followed by intravenous injection of SOLU-MEDROL and other accepted procedures.

There is evidence that the corticoids through their prolonged hemodynamic effect are of value in preventing recurrent attacks of acute anaphylactic reactions. • In sensitivity reactions such as in serum sickness, allergic dermatosis (urticaria) and reactions to insect bites, SOLU-MEDROL is capable of providing relief within 1/2 to 2 hours.

INDICATIONS AND USAGE

Methylprednisolone tablets are indicated in the following conditions: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).

Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Synovitis of osteoarthritis Acute nonspecific tenosynovitis Post-traumatic osteoarthritis Psoriatic arthritis Epicondylitis Acute gouty arthritis 3.