Lisinopril

Hypertension:

Treatment of hypertension.

Heart failure:

Treatment of symptomatic heart failure.

Acute myocardial infarction:

Short-term (6 weeks) treatment of haemodynamically stable patients within 24 hours of an acute myocardial infarction. 1).

LISINOPRIL TABLETS (lisinopril) is indicated in adults for: • Hypertension: in the treatment of essential hypertension and in renovascular hypertension, alone or in combination with thiazide diuretics. A great majority of patients (>80%) with severe hypertension required combination therapy.

• Heart Failure: in the management of symptomatic congestive heart failure as adjunctive treatment with diuretics, and where appropriate, digitalis. Treatment with LISINOPRIL TABLETS should be initiated under close medical supervision, usually in a hospital.

High doses of LISINOPRIL TABLETS reduce the risk of the combined outcomes of mortality and hospitalization (see 4 DOSAGE AND ADMINISTRATION and 10 CLINICAL PHARMACOLOGY). • Acute Myocardial Infarction: in the treatment of hemodynamically stable patients as early as within 24 hours following acute myocardial infarction, to improve survival.

Patients should receive, as appropriate, the standard recommended treatments such as thrombolytics, ASA and beta blocker(s). Therapy with LISINOPRIL TABLETS should be reassessed after 6 weeks. If there is no evidence of symptomatic or asymptomatic left ventricular dysfunction, treatment with LISINOPRIL TABLETS can be stopped.

1 Hypertension Lisinopril tablets, USP, are indicated for the treatment of hypertension in adult patients and pediatric patients 6 years of age and older to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).