Enalapril

Treatment of hypertension:

All grades of essential hypertension and renovascular hypertension.

Treatment of heart failure:

In heart failure, Enalapril 10 mg, tablets should be used as an adjunctive therapy with non-potassium-sparing diuretics and, where appropriate, digitalis. Enalapril 10 mg, tablets have been shown to improve symptoms, retard the progression of the disease, and reduce mortality and hospitalisation.

Prevention of symptomatic heart failure:

When used in asymptomatic patients with left ventricular dysfunction, Enalapril 10 mg, tablets retard the development of symptomatic heart failure, and reduce hospitalisation for heart failure. Prevention of coronary ischaemic events in patients with left ventricular dysfunction: Enalapril 10 mg, tablets reduce both the incidence of myocardial infarction and hospitalisation for unstable angina pectoris.

ENALAPRIL (enalapril maleate) is indicated for:  essential or renovascular hypertension  treatment of symptomatic congestive heart failure Hypertension ENALAPRIL is indicated in the treatment of essential or renovascular hypertension.

It is usually administered in association with other drugs, particularly thiazide diuretics. In using ENALAPRIL consideration should be given to the risk of angioedema (see 7 WARNINGS AND PRECAUTIONS). Congestive Heart Failure ENALAPRIL is indicated in the treatment of symptomatic congestive heart failure usually in combination with diuretics and/or digitalis.

In these patients, enalapril improves symptoms, increases survival, and decreases the frequency of hospitalization (see 14 CLINICAL TRIALS for details and limitations of survival trials). Treatment with ENALAPRIL should be initiated under close medical supervision.

In clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction ≤35%), enalapril decreases the rate of development of overt heart failure and decreases the incidence of hospitalization for heart failure (see 14 CLINICAL TRIALS for details and limitations of survival trials).

INDICATIONS AND USAGE

Hypertension Enalapril maleate is indicated for the treatment of hypertension. Enalapril maleate is effective alone or in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of enalapril maleate and thiazides are approximately additive.

Heart Failure Enalapril maleate is indicated for the treatment of symptomatic congestive heart failure, usually in combination with diuretics and digitalis. In these patients enalapril maleate improves symptoms, increases survival, and decreases the frequency of hospitalization (see CLINICAL PHARMACOLOGY, Heart Failure, Mortality Trials for details and limitations of survival trials).

Asymptomatic Left Ventricular Dysfunction In clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction ≤35 percent), enalapril maleate decreases the rate of development of overt heart failure and decreases the incidence of hospitalization for heart failure (see CLINICAL PHARMACOLOGY, Heart Failure, Mortality Trials for details and limitations of survival trials).