Diphenhydramine
Active ingredient · 2 therapeutic classes
Sold as Sleep Aid · Itch Relief · Nighttime Sleep Aid · dg health sleep aid · Allergy Childrens Allergy
- Drug class
- Aminoalkyl Ethers
- Availability
- Prescription and OTC
- Routes
- Oral, Topical, Intramuscular, Intravenous
- Markets covered
- 3
- Products on record
- 50
- FDA reports (12 mo)
- 9,019
Overview
Plain-language summary, compiled from the cited regulatory records
Diphenhydramine is an antihistamine used for topical applications [1]. It belongs to the drug class of antihistamines for topical use [1].
Diphenhydramine hydrochloride injection is approved for adults and pediatric patients, excluding premature infants and neonates, when oral administration is not practical [1]. It is indicated for the amelioration of allergic reactions to blood or plasma, as an adjunct to epinephrine and other standard measures in anaphylaxis after acute symptoms are controlled, and for other uncomplicated immediate allergic conditions when oral therapy is not suitable [1].
This active ingredient is available under various brand names, including Good Neighbor Pharmacy Childrens Allergy, Nighttime Sleep Aid, and basic care nighttime sleep aid [1]. In the last 12 months, there have been 9019 adverse event reports associated with diphenhydramine [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| US United States | FDA | 27 | May 6, 2026 |
| GB United Kingdom | MHRA | 18 | May 29, 2026 |
| CA Canada | Health Canada | 5 | March 22, 2025 |
USUnited States· FDA
27 products
Uses
Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: itchy, watery eyes sneezing runny nose itching of the nose or throat temporarily relieves these symptoms due to the common cold: sneezing runny nose
How to take
GBUnited Kingdom· MHRA
18 products
Uses
Propain Caplets are indicated in patients older than 12 years of age for the treatment of acute moderate pain which is not considered to be relieved by other analgesics such as paracetamol, ibuprofen or aspirin alone. Propain Caplets may be used in the treatment of headache, migraine, muscular pain, period pain and toothache.
How to take
CACanada· Health Canada
5 products
5 products on record with this regulator. Detailed label text (uses, dosage, side effects) is being ingested — the original document is linked under Sources [3].
Brands in Canada (2)
Drug interactions
Known interactions involving Diphenhydramine. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 368. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]FDA DailyMed · 00f89eee-0edc-40… · revised April 14, 2026 [PDF]
- [2]MHRA (UK) · PL556120017 · revised May 29, 2026
- [3]Health Canada (DPD) · 00596612 · revised March 22, 2025
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.