Adverse effects of paracetamol:
System Organ Class Frequency Adverse Reactions Very Rare Thrombocytopenia, neutropenia, leukopenia. Blood and lymphatic system disorders Not Known Agranulocytosis, haemolytic anaemia in particular in patients with underlying glucose 6- phosphate-dehydrogenase deficiency.
Immune system disorders Not known Hypersensitivity including skin rash may occur. Anaphylactic shock, angioedema. Very Rare Very rare cases of serious skin reactions have been reported. Erythema, urticaria, rash. Skin and subcutaneous tissue disorders Not Known Toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), acute generalized exanthematous pustulosis, fixed drug eruption.
Hepatobiliary disorders Very rare Cytolytic hepatitis, which may lead to acute hepatic failure. 4). Pyroglutamic acidosis may occur as a consequence of low glutathione levels in these patients.
Adverse effects of Codeine:
The most frequent undesirable effects of codeine are constipation and drowsiness. Less frequent effects are nausea, vomiting, sweating, facial flushing, dry mouth, blurred or double vision, dizziness, orthostatic hypotension, malaise, tiredness, headache, anorexia, vertigo, bradycardia, palpitations, respiratory depression, dyspnoea, allergic reactions (itch, skin rash, facial oedema) and difficulties in micturition (dysuria, increased frequency, decrease in amount).
Side effects, which occur rarely, include convulsions, hallucinations, nightmares, uncontrolled muscle movements, muscle rigidity, mental depression and stomach cramps. Very rare cases of pancreatitis have been reported. Regular prolonged use of codeine is known to lead to addiction and symptoms of restlessness and irritability may result when treatment is stopped.
Prolonged use of a painkiller for headaches can make them worse. System Organ Class Frequency Adverse Reactions Immune system disorders Not Known Hypersensitivity. Psychiatric disorders Not Known Confusional state, dysphoriam, euphoria.
Long-term use also entails the risk of drug dependence. Nervous system disorders Not Known Seizure, headache, somnolence, dizziness, sedation. Eye disorders Not Known Miosis. Visuomotor coordination and visual acuity may be adversely affected in a dose-dependent manner at higher doses or in particularly sensitive patients.
Ear and labyrinth disorders Not Known Tinnitus. Skin and subcutaneous tissue Not Known Pruritus. disorders Renal and urinary disorders Not Known Urinary retention. Vascular disorders Not Known Hypotension.
Adverse effects of doxylamine succinate:
Common side effects: CNS effects: Drowsiness (usually diminishes within a few days), paradoxical stimulation, headaches, psychomotor impairment.
Antimuscarinic effects:
Urinary retention, dry mouth, blurred vision, gastrointestinal disturbances, thickened respiratory tract secretions Rare side effects: Hypotension, extrapyramidal effects, dizziness, confusion, depression, sleep disturbances, tremor, convulsions, palpitation, arrhythmia hypersensitivity reactions, blood disorders and liver dysfunction.
Adverse effects of Caffeine Side effects of caffeine include nausea, headache and insomnia. Large doses may cause restlessness, excitement, muscle tremor, tinnitus, scintillating scotoma, tachycardia and extrasystoles. Caffeine increases gastric secretion and may cause gastric ulceration.
System Organ Class Frequency Adverse Reactions Psychiatric disorders Not Known Anxiety, insomnia, restlessness and tremor. Gastrointestinal disorders Not Known Gastric disorders. Cardiac disorders Not Known Heart rate increased. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.