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Drug interaction
A major drug-drug interaction between Diphenhydramine and Zonisamide is recorded in public interaction data. Severity reflects the source classification; it does not describe your individual risk. Do not start, stop, or change either medicine based on this page.
A major interaction can cause a clinically significant - sometimes serious - effect. Prescribers usually avoid this combination, or use it only with close monitoring and dose adjustments.
Do not combine these on your own. If both have been prescribed, tell your pharmacist or doctor so they can confirm it is intended and watch for problems.
Diphenhydramine and Zonisamide are each reported to cause the effects below. Taking them together can make these more likely or more pronounced - one of the ways a drug interaction matters.
Compiled from public adverse-event reports; an overlap, not a confirmed causal mechanism.
DDInter 2.0 (CC-BY 4.0, https://ddinter.scbdd.com)
This is not medical advice. Drugvu is an independent aggregator of public records.