Promethazine
Active ingredient · 2 therapeutic classes
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- Drug class
- Phenothiazine Derivatives
- Availability
- Prescription only
- Routes
- Oral, Intramuscular, Intravenous, Rectal
- Markets covered
- 2
- Products on record
- 40
Overview
Plain-language summary, compiled from the cited regulatory records
Promethazine is an antihistamine for topical use [1]. It belongs to the drug class of antihistamines for topical use (D04AA) [1].
Promethazine is approved for several allergic conditions. These include perennial and seasonal allergic rhinitis, and vasomotor rhinitis [1]. It is also indicated for allergic conjunctivitis caused by inhalant allergens and foods [1]. Additionally, it can be used for mild, uncomplicated allergic skin manifestations like urticaria and angioedema [1]. Promethazine is useful for ameliorating allergic reactions to blood or plasma and for dermographism [1]. It also serves as adjunctive therapy for anaphylactic reactions, after initial control of acute symptoms, alongside epinephrine and other standard treatments [1].
This medication is available under various brand names [1].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 32 | May 22, 2026 |
| US United States | FDA | 8 | January 1, 2026 |
GBUnited Kingdom· MHRA
32 products
Uses
For the symptomatic relief of colds, chills and influenza at night.
How to take
USUnited States· FDA
8 products
Uses
INDICATIONS AND USAGE
Promethazine HCl Suppositories are useful for:
Perennial and seasonal allergic rhinitis. Vasomotor rhinitis. Allergic conjunctivitis due to inhalant allergens and foods. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Amelioration of allergic reactions to blood or plasma.
Dermographism. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Preoperative, postoperative, or obstetric sedation. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
Drug interactions
Known interactions involving Promethazine. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 600. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL446730192 · revised December 5, 2025
- [2]FDA DailyMed · 047b9a7c-586b-46… · revised June 30, 2023 [PDF]
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.