JAMP DOXYCYCLINE

DOSAGE EXCEEDING THE RECOMMENDED DOSAGE MAY RESULT IN AN INCREASED INCIDENCE OF SIDE EFFECTS. Adults The recommended dosage of JAMP Doxycycline Tablets for the majority of susceptible infections is a single loading dose of 200 mg on the first day of treatment followed by a maintenance dosage of 100 mg once daily at the same time each day thereafter.

In the management of more severe infections (particularly chronic infections of the urinary tract), 200 mg should be given daily throughout the treatment period. Therapy should be continued for at least 24-48 hours after symptoms and fever have subsided.

It should be noted, however, that effective antibacterial levels are usually present 24 to 36 hours following discontinuance of doxycycline hyclate therapy. When used in streptococcal infections, therapy should be continued for 10 days to prevent the development of rheumatic fever or glomerulonephritis.

d. for 3 days. For treatment of uncomplicated urethral, endocervical, or vaginal infections in adults associated with Chlamydia trachomatis and Ureaplasma urealyticum: 100 mg, by mouth, twice a day for at least 10 days. No alteration in recommended dosage schedule need be made when treating patients with impaired renal function.

ADMINISTRATION JAMP Doxycycline Tablets should be given with or after a meal in order to minimize the possibility of gastric upset. Antacids and iron preparations impair absorption and should not be given concomitantly to patients taking oral doxycycline hyclate.

Patients should be advised to take JAMP Doxycycline Tablets with a full glass of water, to keep in orthostatic position after the administration and not to go to bed within 1-2 hours after the intake. Prescribing Information JAMP Doxycycline Tablets (Doxycycline Hyclate Tablets, USP) Page 12 of 26 ` PHARMACEUTICAL INFORMATION CHEMISTRY Proper Name: Doxycycline Hyclate Chemical Name: 2-Naphthacenecarboxamide, 4-(dimethyIamino)-1,4,4a,5,5a,6,11,12a octahydro-3,5,10,12,12a-pentahydroxy-6- methyl-1,11-dioxo- monohydrochloride, compd.

9 g/mol Description: Doxycycline hyclate is a yellow crystalline powder. It is freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.

Composition:

JAMP Doxycycline Tablets contain doxycycline hyclate equivalent to 100 mg of doxycycline.

Non-medicinal ingredients:

Colloidal silicon dioxide, D&C Yellow No. 10, FD&C blue No. 2, FD&C Yellow No. 6, FD&C Red No. 40, hypromellose, macrogol, magnesium stearate, microcrystalline cellulose, pregelatinized starch, polysorbate 80, sodium starch glycolate, stearic acid and titanium dioxide.