DOXYCIN TAB

DOSAGE EXCEEDING THE RECOMMENDED DOSAGE MAY RESULT IN AN INCREASED INCIDENCE OF SIDE EFFECTS. Adults The recommended dosage of DOXYCIN CAPSULES AND DOXYCIN TABLETS for the majority of susceptible infections is a single loading dose of 200 mg on the first day of treatment followed by a maintenance dosage of 100 mg once daily at the same time each day thereafter.

In the management of more severe infections (particularly chronic infections of the urinary tract), 200 mg should be given daily throughout the treatment period. Therapy should be continued for at least 24-48 hours after symptoms and fever have subsided.

It should be noted, however, that effective antibacterial levels are usually present 24 to 36 hours following discontinuance of doxycycline hyclate therapy. When used in streptococcal infections, therapy should be continued for 10 days to prevent the development of rheumatic fever or glomerulonephritis.

d. for 3 days. For treatment of uncomplicated urethral, endocervical, or vaginal infections in adults associated with Chlamydia trachomatis and Ureaplasma urealyticum: 100 mg, by mouth, twice a day for at least 10 days. No alteration in recommended dosage schedule need be made when treating patients with impaired renal function.

ADMINISTRATION DOXYCIN CAPSULES AND DOXYCIN TABLETS should be given with or after a meal in order to minimize the possibility of gastric upset. Antacids and iron preparations impair absorption and should not be given concomitantly to patients taking oral doxycycline hyclate.

Patients should be advised to take DOXYCIN CAPSULES AND DOXYCIN TABLETS with a full glass of water, to keep in orthostatic position after the administration and not to go to bed within 1-2 hours after the intake. Prescribing Information – DOXYCIN CAPSULES AND DOXYCIN TABLETS Page 10 of 25 PHARMACEUTICAL INFORMATION CHEMISTRY Proper Name: doxycycline hyclate Chemical Name: 2-Naphthacenecarboxamide, 4-(dimethyIamino)-1,4,4a,5,5a,6,11,12a octahydro-3,5,10,12,12a-pentahydroxy-6- methyl-1,11-dioxo- monohydrochloride, compd.

89 g/mol Description: Doxycycline hyclate is a yellow crystalline powder with a slight ethanolic odour and a bitter taste. The melting point is about 200°C with decomposition. It is soluble in a 1 in 3 dilution with water, 1 in 60 with alcohol and 1 in 4 with methyl alcohol; slightly soluble in chloroform and ether; soluble in solutions of alkali hydroxides and carbonates.

Composition:

DOXYCIN TABLETS contain Doxycycline Hyclate equivalent to 100 mg of doxycycline.

Non-medicinal ingredients:

Allura Red AC (FD&C Red No. 40), Carnauba wax, Hypromellose, Indigo carmine (FD&C Blue No. 2), Magnesium stearate, Microcrystalline cellulose, Polyethylene glycol, Polysorbate 80, Ouinoline Yellow WS (D&C Yellow No. 10), Silicon dioxide colloidal, Sodium starch glycolate, Starch, Stearic acid, Sunset Yellow FCF (FD&C Yellow No.