Doxycycline

Vibramycin has been found clinically effective in the treatment of a variety of infections caused by susceptible strains of Gram-positive and Gram-negative bacteria and certain other micro- organisms. Respiratory tract infections Pneumonia and other lower respiratory tract infections due to susceptible strains of Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae and other organisms.

Mycoplasma pneumoniae. Treatment of chronic bronchitis, sinusitis. Urinary tract infections caused by susceptible strains of Klebsiella species, Enterobacter species, Escherichia coli, Streptococcus faecalis and other organisms. Sexually transmitted diseases Infections due to Chlamydia trachomatis including uncomplicated urethral, endocervical or rectal infections.

Non-gonococcal urethritis caused by Ureaplasma urealyticum (T-mycoplasma). Vibramycin is also indicated in chancroid, granuloma inguinale and lymphogranuloma venereum. Vibramycin is an alternative drug in the treatment of gonorrhoea and syphilis.

DOSAGE EXCEEDING THE RECOMMENDED DOSAGE MAY RESULT IN AN INCREASED INCIDENCE OF SIDE EFFECTS. Adults The recommended dosage of oral Teva-Doxycycline Capsules / Teva- Doxycycline Tablets for the majority of susceptible infections is a single loading dose of 200 mg on the first day of treatment followed by a maintenance dosage of 100 mg once daily at the same time each day thereafter.

In the management of more severe infections (particularly chronic infections of the urinary tract), 200 mg should be given daily throughout the treatment period. Therapy should be continued for at least 24-48 hours after symptoms and fever have subsided.

It should be noted, however, that effective antibacterial levels are usually present 24 to 36 hours following discontinuance of doxycycline hyclate therapy. When used in streptococcal infections, therapy should be continued for 10 days to prevent the development of rheumatic fever or glomerulonephritis.

INDICATIONS AND USAGE

To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline and other antibacterial drugs, doxycycline should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Treatment:

Doxycycline is indicated for the treatment of the following infections: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae. Respiratory tract infections caused by Mycoplasma pneumoniae .