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JAMP DOXYCYCLINE is a brand name for Doxycycline, supplied as a capsule. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
THE DOSAGE OF JAMP DOXYCYCLINE DIFFERS FROM THAT OF DOXYCYCLINE USED TO TREAT INFECTIONS. EXCEEDING THE RECOMMENDED DOSAGE MAY RESULT IN AN INCREASED INCIDENCE OF SIDE EFFECTS INCLUDING THE DEVELOPMENT OF RESISTANT MICROORGANISMS. JAMP Doxycycline 20 mg twice daily as an adjunct following scaling and root planing may be administered for up to 9 months.
Safety beyond 12 months and efficacy beyond 9 months have not been established. JAMP Doxycycline should be administered at least one hour prior to morning and evening meals. Administration of adequate amounts of fluid along with the capsules is recommended to wash down the drug and reduce the risk of esophageal irritation and ulceration (see ADVERSE REACTIONS).
JAMP Doxycycline (Doxycycline Capsules USP) - Product Monograph Page 7 of 17 PHARMACEUTICAL INFORMATION Drug Substance Proper Name: Doxycycline hyclate Chemical Name: (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a- octahydrotetracene-2-carboxamide hydrochloride hemiethanol hemihydrate.
9 g/mol Description: Doxycycline hyclate is a yellow crystalline powder. It is freely soluble in water and in methanol. Sparingly soluble in ethanol (96 per cent). 0 (solution in water containing 10 mg of doxycycline per mL).
Composition:
JAMP Doxycycline contains doxycycline hyclate equivalent to 20 mg of doxycycline. Doxycycline is synthetically derived from oxytetracycline.
Non-medicinal ingredients:
Black iron oxide, croscarmellose sodium, gelatin, lactose monohydrate, magnesium stearate, propylene glycol, potassium hydroxide, shellac, stearic acid, and titanium dioxide. JAMP Doxycycline (Doxycycline Capsules USP) - Product Monograph Page 8 of 17 AVAILABILITY AND DOSAGE FORM JAMP Doxycycline (white opaque cap imprinted with ‘JP’ in black lettering and white opaque body imprinted with ‘DC 20 mg’ in black lettering, size “2” hard gelatin capsules) contains doxycycline hyclate equivalent to 20 mg doxycycline.
Supplied in bottle of 60 capsules. ), protected from excessive humidity. MICROBIOLOGY Doxycycline is a member of the tetracycline class of antibiotics. The dosage of doxycycline achieved with this product during administration is well below the concentration required to inhibit microorganisms commonly associated with adult periodontitis.
Clinical studies with this product demonstrated no effect on total anaerobic and facultative bacteria in plaque samples from patients administered this dose regimen for 9 to 18 months. This product should not be used for reducing the number of or eliminating those microorganisms associated with periodontitis.
While short-term therapy may not lead to alteration of microflora, the long-term exposure effects have not been studied and cannot be predicted. 06 Not Determined Absorption Doxycycline is virtually completely absorbed after oral administration.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Doxycycline in Canada.
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Following 20 mg doxycycline, twice a day, in healthy volunteers, the mean peak concentration in plasma was 790 ng/mL and the average steady-state concentration was 482 ng/mL. The effect of food on the absorption of doxycycline from doxycycline hyclate capsules has not been studied.
Distribution Doxycycline is greater than 90% bound to plasma proteins. 4,6 Metabolism Major metabolites of doxycycline have not been identified. However, enzyme inducers such as barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
JAMP Doxycycline (Doxycycline Capsules USP) - Product Monograph Page 9 of 17 Excretion Doxycycline is excreted in the urine and feces as an unchanged drug. 5,6 Half-life averaged 18 hours in subjects receiving a single 20 mg doxycycline dose.
Special Populations Geriatric Doxycycline pharmacokinetics have not been evaluated in geriatric patients. Pediatric Doxycycline pharmacokinetics have not been evaluated in pediatric patients (see WARNINGS). Gender A study was conducted on 42 subjects where doxycycline pharmacokinetics were compared in men and women.
7-fold higher in women than in men. There were no apparent differences in other pharmacokinetic parameters. Race Differences in doxycycline pharmacokinetics among racial groups have not been evaluated. Renal Insufficiency Studies have shown no significant difference in serum half-life of doxycycline in patients with normal and severely impaired renal function.
Hemodialysis does not alter the half-life of doxycycline. Hepatic Insufficiency Doxycycline pharmacokinetics have not been evaluated in patients with hepatic insufficiency. Drug Interactions See PRECAUTIONS. Clinical Study In a randomized, multi-centered, double-blind, 9-month Phase 3 study involving 190 adult patients with periodontal disease [at least two probing sites per quadrant of between 5 and 9 mm pocket depth (PD) and attachment level (ALv)], the effects of oral administration of 20 mg twice a day of doxycycline hyclate plus scaling and root planing (SRP) were compared to placebo control plus SRP.
Both treatment groups were administered a course of scaling and root planing in 2 quadrants at Baseline. Measurements of ALv, PD and bleeding-on-probing (BOP) were obtained at Baseline, 3, 6, and 9 months from each site about each tooth in the two […]