Sodium Bicarbonate

Treatment of symptoms of gastro-oesophageal reflux such as acid regurgitation, heartburn and indigestion related to reflux, for example, following meals, or during pregnancy, or in patients with symptoms related to reflux oesophagitis.

9 PART III: CONSUMER INFORMATION ...................................... 12 JAMP-ElectroPEG Prescribing Information Page 3 of 14 JAMP-ElectroPEG Polyethylene Glycol 3350 and Electrolytes for Oral Solution, USP PART I: HEALTH PROFESSIONAL INFORMATION SUMMARY PRODUCT INFORMATION Route of Administration Dosage Form / Strength Clinically Relevant Non-medicinal Ingredients Powder for oral solution.

97 g For a complete listing see Dosage Forms, Composition and Packaging sections. INDICATIONS AND CLINICAL USE Adults JAMP-ElectroPEG, a polyethylene glycol (PEG)/electrolytes-based product, is indicated for: • Bowel cleansing prior to colonoscopy or barium enema x-ray examination or surgical procedures requiring a clean colon.

CONTRAINDICATIONS JAMP-ElectroPEG is contraindicated in patients with: • Ileus • Gastric retention • Bowel perforation • Gastrointestinal obstruction • Toxic colitis • Toxic megacolon • Hypersensitivity to this drug or to any ingredient in the formulation or component of the container.

INDICATIONS AND USAGE

Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis.

Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products.

Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. , insulin in uncomplicated diabetes, blood volume restoration in shock. But since an appreciable time interval may elapse before all of the ancillary effects are brought about, bicarbonate therapy is indicated to minimize risks inherent to the acidosis itself.