Candesartan

Candesartan cilexetil is indicated for the • Treatment of primary hypertension in adults. • Treatment of hypertension in children and adolescents aged 6 to <18 years. 1).

CANDESARTAN CILEXETIL (candesartan cilexetil tablets) is indicated for: • Hypertension o The treatment of mild to moderate essential hypertension. o CANDESARTAN CILEXETIL may be used alone or concomitantly with thiazide diuretics. o The safety and efficacy of concurrent use with calcium channel blockers have not been established.

• Heart Failure o The treatment of NYHA Class II and III heart failure with ejection fraction ≤ 40% in addition to standard therapy, with or without an ACE inhibitor. 3 Pediatrics, 14 CLINICAL TRIALS). • Heart Failure The safety and efficacy of candesartan cilexetil in the treatment of heart failure has not been established in children and adolescents <18 years.

2 Geriatrics Geriatrics (> 65 years of age): No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

1 INDICATIONS AND USAGE Candesartan cilexetil tablets are an angiotensin II receptor blocker (ARB) indicated for: · Treatment of hypertension in adults and children 1 to <17 years of age, to lower blood pressure. 1). 1 Hypertension Candesartan cilexetil tablets are indicated for the treatment of hypertension in adults and in children 1 to <17 years of age, to lower blood pressure.

Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).