ASPIRIN

Posology Adults & children over 16 years: 1 - 3 tablets every four hours, or as directed by a doctor. Not more than 4 doses in 24 hours. Elderly A lower dose is recommended.

Paediatric population:

Do not give to children aged under 16 years, unless specifically indicated (eg for Kawasaki’s disease) Method of administration The tablets to be taken orally with water.

Adverse effects of aspirin treatment which have been reported include:

Blood and lymphatic system disorders Anaemia may occur following chronic gastrointestinal blood loss or acute haemorrhage. Aspirin prolongs bleeding time, and bleeding disorders, such as epistaxis, purpura and intracranial haemorrhage have occasionally been reported.

Nervous system disorders:

Mental confusion.

Dizziness Ear and labyrinth disorders:

Hearing disturbances (such as tinnitus) vertigo Respiratory, thoracic and mediastinal disorders; Aspirin may precipitate bronchospasm and induce asthma in susceptible patients. Dyspnoea also have been reported.

Gastrointestinal disorders:

Gastric irritation, dyspepsia, nausea, vomiting, gastrointestinal, erosions, ulcerations, gastritis. In some cases of intensive use may induce gastrointestinal haemorrhage, occasionally major, which may manifest as melaena or haematemesis.

General disorders and administration site conditions Hypersensitivity reactions include skin rashes, urticaria and angioedema Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.

It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for the MHRA Yellow Card in the Google Play or Apple App Store.

There is a possible association between aspirin and Reye’s syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and liver and can be fatal. g. for Kawasaki’s disease). Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose- galactose malabsorption should not take aspirin.

Patients should be warned: • not to exceed the stated dose. • not to take aspirin if they have ever suffered from stomach ulcers. • to keep medicines out of the reach of children. Caution is required if administrated to patients suffering from, or with a previous history of bronchial asthma.

May produce haemolysis is some glucose-6-phoshate dehydrogenase deficient individuals.

Aspirin is contraindicated in patients with; • Active peptic ulceration or a history of peptic ulceration. • Haemophilia, haemorrhagic disease or a history of bleeding disorders. • Gout or a history of gout. g. asthma, rhinitis, angioedema or urticaria), other NSAIDs or other tablet excipients • Doses > 100 mg/day during the third trimester of pregnancy