WOCKHARDT DUAL ACTION PAIN CONTROL

Posology Adults, the elderly and children over 16 years of age: 1-2 caplets every 4-6 hours. Maximum of 8 tablets in any 24 hour period. g. for Kawasaki’s disease). The dose should not be repeated more frequently than every 4 hours. Do not take for more than 3 days without consulting a doctor.

Gastro-intestinal irritation may be reduced by taking aspirin with or immediately after food. Method of administration For oral administration. Swallow whole with water. Do not chew.

). 5 Interactions). g. chronic alcoholism) who were treated with paracetamol at therapeutic dose for a prolonged period or a combination of paracetamol and flucloxacillin. If HAGMA due to pyroglutamic acidosis is suspected, prompt discontinuation of paracetamol and close monitoring, is recommended.

The measurement of urinary 5-oxoproline may be useful to identify pyroglutamic acidosis as underlying cause of HAGMA in patients with multiple risk factors. Caffeine Care is advised in the administration of caffeine to patients with cardiac disease.

g coffee, tea and some canned drinks) should be avoided while taking this product. Aspirin Caution should be exercised in patients with asthma, allergic disease, , impairment of hepatic or renal function (avoid if severe), impaired cardiac function, uncontrolled hypertension and dehydration, dyspepsia and in patients with nasal polyps or a history of nasal polyps.

Aspirin should be used with caution in patients with infections, since symptoms such as fever and inflammation may be masked. The elderly may be more susceptible to the toxic effects of salicylates. Continuous prolonged use of aspirin should be avoided in the elderly because of the risk of gastrointestinal bleeding.

Care should be taken giving aspirin to patients with glucose-6-phosphate dehydrogenase deficiency as haemolytic anaemia may occur. Aspirin may interfere with insulin and glucagon in diabetes. Aspirin prolongs bleeding time, mainly by inhibiting platelet aggregation, and therefore it should be discontinued several days before scheduled surgical procedures.

Renal, hepatic and haematological status should be monitored during prolonged and high dose aspirin therapy. There is some evidence that drugs which inhibit cyclo-oxygenase /prostaglandin synthesis may cause impairment of female fertility by an effect on ovulation.

Paracetamol Care is advised in the administration of paracetamol to patients with renal or hepatic impairment. The hazards of overdose are greater in those with alcoholic liver disease. Paracetamol should be given with care to patients with alcohol dependence.

Paracetamol is well tolerated by the majority of people with asthma. However a small percentage of aspirin sensitive asthmatics are also sensitive to paracetamol. 8 Undesirable effects). Caution should be exercised when using paracetamol prior to (less than 72 hours) or concurrently with intravenous busulfan (see section

1. 1). In patients with a history of hypersensitivity to aspirin (or any of the excipients) or any other NSAIDs and in patients in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or other NSAIDs.

4 – aspirin and Reye’s syndrome). • Patients with haemophilia, other coagulopathies or concurrent anticoagulant therapy. • Gout • Doses > 100mg/day during the third trimester of pregnancy. Caffeine Patients with active peptic ulcerations or a history of peptic ulceration.