POST MI

The advice of a doctor should be sought before commencing therapy for the first time. The usual dosage, for long term use, is 75-150mg daily. In some circumstances, a higher dose may be appropriate, especially in the short term, and up to 300mg a day may be used on the advice of a doctor.

g. for Kawasaki’s disease).

Adverse effects of aspirin treatment which have been reported include:

Blood and lymphatic system disorders: Anaemia may occur following chronic gastrointestinal blood loss or acute haemorrhage. Aspirin prolongs bleeding time, and bleeding disorders, such as epistaxis, purpura and intracranial haemorrhage have occasionally been reported.

Nervous system disorders:

Mental confusion. Dizziness Ear and labyrinth disorders: hearing disturbances (such as tinnitus), vertigo Respiratory, thoracic and mediastinal disorders; Aspirin may precipitate bronchospasm and induce asthma in susceptible patients.

Dyspnoea also have been reported. Gastrointestinal disorders: gastric irritation, dyspepsia, nausea, vomiting, gastrointestinal erosions, ulcerations, gastritis. In some cases of intensive use may induce gastrointestinal haemorrhage, occasionally major, which may manifest as melaena or haematemesis.

Immune system disorders:

Hypersensitivity reactions include skin rashes, urticaria and angioedema Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.

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Before commencing long term aspirin therapy, for the management of cardiovascular and cerebrovascular disease, patients should consult their doctor who can advise on the relative benefits versus the risks for the individual patient.

Administer with caution in the presence of allergic disease, renal or hepatic impairment, dehydration. There is a possible association between aspirin and Reye’s syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and liver and can be fatal.

g. for Kawasaki’s disease). Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine. Patients should be warned: • not to exceed the stated dose.

• not to take aspirin if they have ever suffered from stomach ulcers. • to keep medicines out of the reach of children. Caution is required if administrated to patients suffering from, or with a previous history of bronchial asthma. May produce haemolysis is some glucose-6-phoshate dehydrogenase deficient individuals This medicine contains less than 1 mmol sodium (23 mg) per 75mg tablet that is to say essentially ‘sodium-free’.

Aspirin is contraindicated in patients with; • active peptic ulceration or a history of peptic ulceration. • Haemophilia, haemorrhagic disease or a history of bleeding disorders. • Gout or a history of gout. g. asthma, rhinitis, angioedema or urticaria), other NSAIDs or other tablet excipients • During the third trimester of pregnancy • children under 16 (except for the treatment of Still’s disease), • breast feeding,.

• concurrent anticoagulant therapy.