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ASPIRIN is a brand name for Aspirin (also known as Acetylsalicylic Acid). The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: For the secondary prevention of thrombotic cerebrovascular or cardiovascular disease, following by-pass surgery and in patients suffering from unstable angina.
Verbatim from this product's MHRA label. Tap a section to expand.
Posology The tablets should be dispersed in water before administration. The advice of a doctor should be sought before commencing therapy for the first time. The usual dosage for long term use is 1-2 tablets (75-150mg) once daily. In some circumstances a higher dose may be appropriate, especially in the short- term, and up to 4 tablets (300mg) a day may be used on the advice of a doctor.
4). Treatment should be reviewed at regular intervals. g. 4). Method of Administration To be dispersed in water for oral administration.
Side effects are grouped on the basis of System Organ Class. Within each system organ class the frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000) and not known (cannot be estimated from the available data) System Organ Class Adverse Reactions and Frequency Blood and lymphatic system disorders Common: Increased bleeding tendencies.
Rare:
Thrombocytopenia, granulocytosis, aplastic anaemia.
Not known:
Cases of bleeding with prolonged bleeding time such as epistaxis, gingival bleeding. Symptoms may persist for a period of 4–8 days after acetylsalicylic acid discontinuation. As a result there may be an increased risk of bleeding during surgical procedures.
Existing (haematemesis, melaena) or occult gastrointestinal bleeding, which may lead to iron deficiency anaemia (more common at higher doses). haemolytic anaemia, hypoprothrombinaemia, pancytopenia, elevated transaminase levels.
Immune system disorders Rare:
Hypersensitivity reactions, angio-oedema, allergic oedema, anaphylactic reactions including shock.
Metabolism and digestive system disorders Not known:
Hyperuricemia.
Nervous system disorders Rare:
Intracranial haemorrhage Not known: Headache, vertigo.
Ear and labyrinth disorders Not known:
Reduced hearing ability; tinnitus.
Vascular disorders Rare:
Aspirin is not suitable for use as an anti-inflammatory/analgesic/antipyretic. Before commencing long-term aspirin therapy for the management of cardiovascular or cerebrovascular disease, patients should consult their doctor who can advise on the relative benefits versus the risks for the individual patient.
Paediatric population There is a possible association between aspirin and Reye’s syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and liver, and can be fatal. g. for Kawasaki’s disease).
g. tooth extraction). Use with caution before surgery, including tooth extraction. Temporary discontinuation of treatment may be necessary. Aspirin is not recommended during menorrhagia where it may increase menstrual bleeding. Aspirin is to be used with caution in cases of hypertension and when patients have a past history of gastric or duodenal ulcer or haemorrhagic episodes or are undergoing therapy with anticoagulants.
Patients should report any unusual bleeding symptoms to their physician. If gastrointestinal bleeding or ulceration occurs the treatment should be withdrawn. Aspirin should be used with caution in patients with moderately impaired renal or hepatic function (contraindicated if severe), or in patients who are dehydrated since the use of NSAIDs may result in deterioration of renal function.
Liver function tests should be performed regularly in patients presenting slight or moderate hepatic insufficiency. Aspirin may promote bronchospasm and asthma attacks or other hypersensitivity reactions. Risk factors are existing asthma, hay fever, nasal polyps or chronic respiratory diseases.
g. with skin reactions, itching or urticaria). 8). Aspirin should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. 2). Where prolonged therapy is required, patients should be reviewed regularly.
g. Kawasaki’s disease).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Aspirin in United Kingdom.
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Haemorrhagic vasculitis.
Respiratory, thoracic and mediastinal disorders Uncommon:
Rhinitis, dyspnoea.
Rare:
Bronchospasm, asthma attacks.
Not known:
Worsening of asthma Reproductive system and mammary disorders Rare: Menorrhagia Gastrointestinal disorders Common: Dyspepsia.
Rare:
Severe gastrointestinal haemorrhage, nausea, vomiting.
Not known:
Gastric or duodenal ulcers, erosions and perforation, which can occasionally be major (may develop bloody or black tarry stools, severe stomach pain and vomiting blood), diarrhoea, gastrointestinal irritation (mild stomach pain, heartburn, vomiting and nausea).
Fatalities have occurred.
Hepatobiliary disorders Not known:
Hepatic insufficiency, hepatitis (particularly in patients with SLE or connective tissue disease).
Skin and subcutaneous tissue disorders Uncommon:
Urticaria.
Rare:
Steven-Johnsons syndrome, Lyells syndrome, purpura, erythema nodosum, erythema multiforme.
Renal and urinary tract disorders Not known:
Impaired renal function, salt and water retention. Salicylism - mild chronic salicylate intoxication may occur after repeated administration of large doses, symptoms include dizziness, tinnitus, deafness, sweating, nausea, vomiting, headache and mental confusion, and may be controlled by reducing the dose.
Paediatric population Aspirin may be associated with the development of Reye’s Syndrome (encephalopathy and hepatic failure) in children presenting with an acute febrile illness. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
e. 5). If the combination cannot be avoided, close observation for signs of bleeding is recommended. 5). Acetylsalicylic acid in low doses reduces uric acid excretion. 5). 5). 5).
Medication Overuse Headache (MOH):
After long term treatment with analgesics, headache may develop or aggravate. Headache caused by overuse of analgesics (MOH - medication- overuse headache) should be suspected in patients who have frequent or daily headaches despite (or because of) regular use of analgesics.
Patients with medication overuse headache should not be treated by increasing the dose. In such cases the use of analgesics should be discontinued in consultation with a doctor. Aspirin Dispersible tablets contain lactose Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine, as it contains lactose.
Aspirin Dispersible tablets contains saccharin sodium This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.