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Spironolactone and Diphenhydramine: Moderate Interaction - Drugvu

🏠›Spironolactone›Interaction with Diphenhydramine

Spironolactone + Diphenhydramine

Drug interaction

Moderate interaction

A moderate drug-drug interaction between Spironolactone and Diphenhydramine is recorded in public interaction data. Severity reflects the source classification; it does not describe your individual risk. Do not start, stop, or change either medicine based on this page.

What “moderate” means

A moderate interaction can matter in some people. The combination is sometimes used, but usually with caution - monitoring, timing changes, or dose adjustments.

What to do

Mention this combination to your pharmacist or prescriber. Do not stop either medicine without advice.

Side effects reported for both

Spironolactone and Diphenhydramine are each reported to cause the effects below. Taking them together can make these more likely or more pronounced - one of the ways a drug interaction matters.

DyspnoeaFatigueNauseaHeadacheDizzinessCough

Compiled from public adverse-event reports; an overlap, not a confirmed causal mechanism.

The two medicines

Active ingredient

Spironolactone

Aldosterone Antagonists

Uses, side effects, dosage →· 598 recorded interactions

Active ingredient

Diphenhydramine

Antihistamines For Topical Use

Uses, side effects, dosage →· 368 recorded interactions

Source

DDInter 2.0 (CC-BY 4.0, https://ddinter.scbdd.com)

This is not medical advice. Drugvu is an independent aggregator of public records.