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Drug interaction
A moderate drug-drug interaction between Alprazolam and Diphenhydramine is recorded in public interaction data. Severity reflects the source classification; it does not describe your individual risk. Do not start, stop, or change either medicine based on this page.
A moderate interaction can matter in some people. The combination is sometimes used, but usually with caution - monitoring, timing changes, or dose adjustments.
Mention this combination to your pharmacist or prescriber. Do not stop either medicine without advice.
Alprazolam and Diphenhydramine are each reported to cause the effects below. Taking them together can make these more likely or more pronounced - one of the ways a drug interaction matters.
Compiled from public adverse-event reports; an overlap, not a confirmed causal mechanism.
DDInter 2.0 (CC-BY 4.0, https://ddinter.scbdd.com)
This is not medical advice. Drugvu is an independent aggregator of public records.