Sincalide

Kinevac (sincalide) is indicated for: • Inducing contraction of the gallbladder during cholecystography. In many instances, the cystic and common bile ducts can also be visualized, especially if viewed 1 to 3 minutes after injection of Kinevac (sincalide).

, to determine the degree of cholesterol saturation. , in suspected cancer of the pancreas. • The relief of postoperative ileus uncomplicated by inflammatory processes such as pancreatitis and peritonitis or by the presence of tumors or other obstructions in the lower digestive tract.

• Decreasing the small bowel transit time of contrast media. 1 Pediatrics Pediatrics (<18 years): The safety and efficacy of Kinevac in pediatric patients has not been established; therefore, Health Canada has not authorized an indication for pediatric use.

2 Geriatrics Geriatrics (>65 years of age): Clinical studies of Kinevac did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

1 INDICATIONS AND USAGE Kinevac is indicated in adults to: to stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals; to stimulate pancreatic secretion in combination with secretin prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology; to accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract.

Kinevac is a cholecystokinin (CCK) analog indicated in adults to: stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals.

( 1 ) stimulate pancreatic secretion in combination with secretin prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology. ( 1 ) accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract.