Oxacillin
Beta-Lactamase Resistant Penicillins
- Drug class
- Beta-Lactamase Resistant Penicillins
- Availability
- Prescription only
- Routes
- Intramuscular, Intravenous
- Markets covered
- 1
- Products on record
- 2
- FDA reports (12 mo)
- 34
Overview
Plain-language summary, compiled from the cited regulatory records
Oxacillin is an antibiotic belonging to the drug class of beta-lactamase resistant penicillins [1]. It is approved for treating infections caused by penicillinase-producing staphylococci that are susceptible to the drug [1]. Initial cultures and susceptibility tests are recommended to identify the causative organism and confirm its susceptibility to oxacillin [1].
Oxacillin is available under various brand names [1]. In the past 12 months, there have been 34 adverse event reports associated with oxacillin [2]. The most frequently reported adverse events include Drug Reaction With Eosinophilia And Systemic Symptoms, Drug Ineffective, Eosinophilic Myocarditis, Product Use In Unapproved Indication, and Renal Failure [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| US United States | FDA | 2 | October 24, 2025 |
USUnited States· FDA
2 products
Uses
INDICATIONS AND USAGE
Oxacillin is indicated in the treatment of infections caused by penicillinase producing staphylococci which have demonstrated susceptibility to the drug. Cultures and susceptibility tests should be performed initially to determine the causative organism and its susceptibility to the drug (See CLINICAL PHARMACOLOGY - Susceptibility Test Methods ).
Oxacillin may be used to initiate therapy in suspected cases of resistant staphylococcal infections prior to the availability of susceptibility test results. Oxacillin should not be used in infections caused by organisms susceptible to penicillin G.
If the susceptibility tests indicate that the infection is due to an organism other than a resistant Staphylococcus , therapy should not be continued with oxacillin. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Oxacillin for Injection, USP and other antibacterial drugs, Oxacillin for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
Drug interactions
Known interactions involving Oxacillin. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]FDA DailyMed · 152758c0-d225-47… · revised August 13, 2025 [PDF]
- [2]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.