Nadolol

Angina:

APO-NADOLOL (nadolol) is indicated for prophylaxis of angina pectoris.

Hypertension:

APO-NADOLOL is indicated in patients with mild or moderate hypertension. APO-NADOLOL is usually used in combination with other drugs, particularly a thiazide diuretic. However, it may be tried alone as an initial agent in those patients in whom, in the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic.

The combination of nadolol with a diuretic has been found to be compatible and generally more effective than nadolol alone. In a few cases where peripheral vasodilators were used with nadolol, no evidence of incompatibility was seen.

APO-NADOLOL is not recommended for the emergency treatment of hypertensive crises. Page 5 of

INDICATIONS AND USAGE

Angina Pectoris Nadolol tablets, USP are indicated for the long-term management of patients with angina pectoris. Hypertension Nadolol tablets, USP are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Nadolol.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

Nadolol is indicated in the management of:

Angina Pectoris: For the long-term management of patients with angina pectoris by continuous medication.

Hypertension:

For the long-term management of essential hypertension, either alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.

Arrhythmias:

For the treatment of cardiac tachyarrhythmias.

Migraine:

For the prophylactic management of migraine headache. The efficacy of Nadolol in the treatment of a migraine attack that has already started has not been established, and Nadolol is not indicated for such use.

Thyrotoxicosis: