Metolazone

INDICATIONS AND USAGE

Metolazone is indicated for the treatment of salt and water retention including: • edema accompanying congestive heart failure; • edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.

Metolazone is also indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class. Mykrox ® tablets, a more rapidly available form of metolazone, are intended for the treatment of new patients with mild to moderate hypertension.

A dose titration is necessary if Mykrox ® tablets are to be substituted for Zaroxolyn ® tablets and other formulations of metolazone that share its slow and incomplete bioavailability, in the treatment of hypertension. Usage In Pregnancy The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.

Xaqua is indicated for the treatment of • oedema related to kidney diseases, including the nephrotic syndrome and states of impaired renal function • oedema related to congestive heart failure Xaqua is also indicated for the treatment of mild and moderate hypertension, alone or in combination with other antihypertensive medicines of a different class.

ZAROXOLYN (metolazone tablets) is indicated for:  the treatment of edema accompanying congestive heart failure and edema accompanying renal diseases including the nephrotic syndrome, and states of diminished renal function.  the management of mild to moderate essential hypertension, alone or in combination with other antihypertensive drugs of a different class.

3 Pediatrics). 2 Geriatrics Geriatrics: Due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy, elderly patients should be treated with caution, usually starting at the low end of the dosing range.