Indapamide

COVERSYL® PLUS LD (perindopril erbumine / indapamide) is indicated for the initial treatment of mild to moderate essential hypertension. COVERSYL® PLUS and COVERSYL® PLUS HD (perindopril erbumine / indapamide) are indicated in the treatment of mild to moderate essential hypertension in patients for whom combination therapy is appropriate.

COVERSYL® PLUS and COVERSYL® PLUS HD are not indicated for initial therapy. Patients in whom perindopril and indapamide are initiated simultaneously can develop symptomatic hypotension (see 9 DRUG INTERACTIONS – Drug-Drug Interactions - Concomitant ACE Inhibitor and Diuretic Therapy).

Patients should be titrated on the individual drugs. If the fixed combination represents the dosage determined by this titration, the use of COVERSYL® PLUS or COVERSYL® PLUS HD may prove to be more convenient in the management of patients.

If during maintenance therapy dosage adjustment is necessary, it is advisable to use individual drugs (see 4 DOSAGE AND ADMINISTRATION). The safety and efficacy of COVERSYL® PLUS LD / COVERSYL® PLUS / COVERSYL® PLUS HD in renovascular hypertension and in congestive heart failure have not been established and therefore, their use in this condition is not recommended.

Indapamide Teva is indicated in essential hypertension in adults.

INDICATIONS

Indapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs. Indapamide tablets are also indicated for the treatment of salt and fluid retention associated with congestive heart failure.

Usage in Pregnancy :

The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard (see PRECAUTIONS below). Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Indapamide is indicated in pregnancy when edema is due to pathologic causes, just as it is in the absence of pregnancy (however, see PRECAUTIONS below).