Mannitol

Bronchitol is indicated for the treatment of cystic fibrosis (CF) in adults aged 18 years and above as an add-on therapy to best standard of care.

For Intravenous Injection General Recommendations:

Give Mannitol Injection, USP only intravenously. The total dosage, concentration and rate of administration should be governed by the nature and severity of the condition being treated, fluid requirement and urinary output. Usual adult dosage ranges from 50 to 200 g in 24 hours, but in most instances, an adequate response will be achieved at a dosage of approximately 100 g in 24 hours.

The rate is usually adjusted to maintain an adequate urine flow (at least 30 to 50 mL / hr).

Test Dose:

In marked oliguria or inadequate renal function, a test dose of mannitol should be given. 2 g / kg (about 50 mL of a 25% solution) infused in three to five minutes to produce an adequate urine flow (at least 30 to 50 mL / hr). If urine flow does not increase within two or three hours, a second test dose may be given.

1 INDICATIONS AND USAGE OSMITROL is indicated for: • The reduction of intracranial pressure and treatment of cerebral edema; • The reduction of elevated intraocular pressure. OSMITROL is an osmotic diuretic, indicated for the reduction of: • intracranial pressure and treatment of cerebral edema.

( 1 ) • elevated intraocular pressure. ( 1 )

Bronchitol is indicated for the treatment of cystic fibrosis (CF) in adults aged 18 years and above as an add-on therapy to best standard of care.