Hydroxocobalamin
Active ingredient · 2 therapeutic classes
Sold as Cyanokit
- Drug class
- Vitamin B12 (Cyanocobalamin and Analogues)
- Availability
- See label
- Routes
- Intravenous
- Markets covered
- 3
- Products on record
- 7
Overview
Hydroxocobalamin is an active pharmaceutical ingredient in the Vitamin B12 (Cyanocobalamin and Analogues) group (B03BA). The information below is compiled per regulator from the product labels on record, with direct links to the original documents.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 5 | May 15, 2026 |
| EU European Union | EMA | 1 | December 16, 2025 |
| CA Canada | Health Canada | 1 | March 22, 2025 |
GBUnited Kingdom· MHRA
5 products
Uses
Treatment of Addisonian Pernicious anaemia. Prophylaxis and treatment of other macrocytic anaemias associated with Vitamin B12 deficiency. Treatment of Tobacco amblyopia. Treatment of Leber’s optic atrophy.
How to take
EUEuropean Union· EMA
1 product
Uses
Treatment of known or suspected cyanide poisoning in all age ranges. 4).
How to take
CACanada· Health Canada
1 product
Uses
32 CYANOKIT® Product Monograph Page 3 of 34 PrCYANOKIT® Hydroxocobalamin Powder for Infusion PART I: HEALTH PROFESSIONAL INFORMATION SUMMARY PRODUCT INFORMATION Route of Administration Dosage Form / Strength Clinically Relevant Nonmedicinal Ingredients intravenous Each vial contains: 1 × 5 g powder for infusion Final concentration after reconstitution is 25 mg/mL For a complete listing see Dosage Forms, Composition and Packaging section.
INDICATIONS AND CLINICAL USE Cyanokit contains hydroxocobalamin, an antidote indicated for the treatment of known or suspected cyanide poisoning. Cyanokit is to be administered together with appropriate decontamination and supportive measures.
Identifying patients with cyanide poisoning:
Cyanide poisoning may result from inhalation, ingestion, or dermal exposure to various cyanide- containing compounds, including smoke from closed space fires. Sources of cyanide poisoning include hydrogen cyanide and its salts, cyanogens, including cyanogenic plants, aliphatic nitriles, or prolonged exposure to sodium nitroprusside.
Drug interactions
Known interactions involving Hydroxocobalamin. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL200750691 · revised May 15, 2026
- [2]European Medicines Agency · EMEA/H/C/000806 · revised December 16, 2025
- [3]Health Canada (DPD) · 02375370 · revised March 22, 2025
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.