Gentamicin

Indications : gentamicin is indicated in bacteraemia, urinary tract infections, chest infections, severe neonatal infections and other serious systemic infections due to susceptible organisms, in adults and children including neonates.

1. Consideration should be given to official local guidance on the appropriate use of antibacterial agents.

Gentamicin Injection USP (gentamicin sulfate) is clinically effective in serious infections caused by susceptible strains of the following bacteria: Pseudomonas aeruginosa, Proteus species (indole negative and indole positive), Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Serratia marcescens, and Staphylococcus species (methicillin-susceptible strains only).

Gentamicin Injection USP (gentamicin sulfate) may be considered for the treatment of Staphylococcus infections when other less potentially toxic drugs are contraindicated and bacterial susceptibility tests and clinical judgment indicate its use.

The use of gentamicin is indicated in the treatment of serious infections caused by laboratory determined susceptible bacteria, with due regard for relative antibiotic toxicity. Therefore, the drug should be considered for treatment of:  Bacteremia  Respiratory tract infections  Urinary tract infections  Infected wounds: surgical and traumatic  Bone and soft tissue infections, including peritonitis and burns complicated by sepsis In the majority of cases bacteriologic cultures should be obtained initially to identify the causative organism(s) and to determine susceptibility to gentamicin.

INDICATIONS AND USAGE:

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Gentamicin Injection, USP and other antibacterial drugs, Gentamicin Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Gentamicin Injection, USP is indicated in the treatment of serious infections caused by susceptible strains of the following microorganisms: Pseudomonas aeruginosa, Proteus species (indole-positive and indole-negative), Escherichia coli, Klebsiella-Enterobacter-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative).