Gentamicin

Gentamicin is an aminoglycoside antibiotic with broad-spectrum bactericidal activity. , Proteus spp. , Citrobacter spp. and Providencia spp. Consideration should be given to official local guidance on the appropriate use of antibacterial agents.

Gentamicin Injection USP (gentamicin sulfate) is clinically effective in serious infections caused by susceptible strains of the following bacteria: Pseudomonas aeruginosa, Proteus species (indole negative and indole positive), Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Serratia marcescens, and Staphylococcus species (methicillin-susceptible strains only).

Gentamicin Injection USP (gentamicin sulfate) may be considered for the treatment of Staphylococcus infections when other less potentially toxic drugs are contraindicated and bacterial susceptibility tests and clinical judgment indicate its use.

The use of gentamicin is indicated in the treatment of serious infections caused by laboratory determined susceptible bacteria, with due regard for relative antibiotic toxicity. Therefore, the drug should be considered for treatment of:  Bacteremia  Respiratory tract infections  Urinary tract infections  Infected wounds: surgical and traumatic  Bone and soft tissue infections, including peritonitis and burns complicated by sepsis In the majority of cases bacteriologic cultures should be obtained initially to identify the causative organism(s) and to determine susceptibility to gentamicin.

INDICATIONS AND USAGE

Gentamicin sulfate ophthalmic solution is indicated in the topical treatment of ocular bacterial infections including conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, and dacryocystitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Serratia marcescens.