Etomidate

INDICATIONS & USAGE SECTION

Etomidate Injection is indicated by intravenous injection for the induction of general anesthesia. When considering use of Etomidate Injection, the usefulness of its hemodynamic properties (see CLINICAL PHARMACOLOGY ) should be weighed against the high frequency of transient skeletal muscle movements (see ADVERSE REACTIONS ).

Intravenous Etomidate Injection is also indicated for the supplementation of subpotent anesthetic agents, such as nitrous oxide in oxygen, during maintenance of anesthesia for short operative procedures such as dilation and curettage or cervical conization.

Hypnomidate is an intravenous induction agent of anaesthesia.

TOMVI™ is indicated for use in health care settings by appropriately trained health care providers in the fields of emergency medicine or anesthesia for:  The induction of general anesthesia  The supplementation of subpotent anesthetic agents during anesthesia for short operative procedures such as dilation and curettage or cervical conization.

1 Pediatrics (< 18 years) Based on the data submitted and reviewed by Health Canada, the safety and efficacy of TOMVI™ in pediatric patients has not been established; therefore, Health Canada has not authorized an indication for pediatric use.

2 Geriatrics (≥ 65 years of age): Evidence from clinical studies and experience suggests that use in the geriatric population is not associated with differences in safety or effectiveness. Reduced doses of TOMVI™ should be considered based on the physical condition of the patient (See WARNINGS AND PRECAUTIONS, Special Populations, Geriatrics, and DOSAGE AND ADMINISTRATION, Recommended Dose and Dosage Adjustment).