Estrone
Active ingredient · 2 therapeutic classes
Sold as Estrogen · Cyclease PMS
- Drug class
- Natural and Semisynthetic Estrogens, Plain
- Availability
- Over-the-counter
- Routes
- Oral, Vaginal
- Markets covered
- 2
- Products on record
- 3
- FDA reports (12 mo)
- 4
Overview
Plain-language summary, compiled from the cited regulatory records
Estrone is a type of estrogen that belongs to the drug class of Natural and Semisynthetic Estrogens, Plain [1]. It is approved for the temporary relief of premenstrual symptoms [1]. These symptoms can include bloating, water retention, minor aches, lower back pain, discomfort, emotional changes, and irritability [1].
Estrone is available under various brand names, including Cyclease PMS and Estrogen [1]. In the past 12 months, there have been 4 adverse event reports associated with this active ingredient [2]. The most frequently reported adverse events include Acute Respiratory Distress Syndrome, Cardiac Arrest, Cardiac Failure Congestive, Colitis Ulcerative, and Disseminated Intravascular Coagulation [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| US United States | FDA | 2 | March 12, 2026 |
| CA Canada | Health Canada | 1 | March 22, 2025 |
USUnited States· FDA
2 products
Uses
Temporary relieves premenstrual symptoms such as: bloating, water retention, minor aches, lower back pain, discomfort, emotional changes, irritability
How to take
CACanada· Health Canada
1 product
Uses
AND CLINICAL USE.......................................................................... 3 CONTRAINDICATIONS .............................................................................................. 3 WARNINGS AND PRECAUTIONS .............................................................................
4 ADVERSE REACTIONS ............................................................................................. 11 DRUG INTERACTIONS ............................................................................................. 13 DOSAGE AND ADMINISTRATION .........................................................................
16 OVERDOSAGE ........................................................................................................... 17 ACTION AND CLINICAL PHARMACOLOGY ........................................................ 18 STORAGE AND STABILITY .....................................................................................
Drug interactions
Known interactions involving Estrone. Select one for details. This list is informational and not a complete interaction checker.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]FDA DailyMed · 09ff0633-2992-4a… · revised May 30, 2023 [PDF]
- [2]Health Canada (DPD) · 00727369 · revised March 22, 2025
- [3]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.