Estradiol
Natural and Semisynthetic Estrogens, Plain
Sold as Climara Pro · BIJUVA · ESTRING · DIVIGEL · IMVEXXY
- Drug class
- Natural and Semisynthetic Estrogens, Plain
- Availability
- Prescription only
- Routes
- Vaginal, Transdermal, Oral, Topical
- Markets covered
- 3
- Products on record
- 209
- FDA reports (12 mo)
- 9,125
Overview
Plain-language summary, compiled from the cited regulatory records
Estradiol is a type of hormone that belongs to the drug class of natural and semisynthetic estrogens [1]. It is approved for treating moderate to severe symptoms associated with vulvar and vaginal atrophy, which is often a result of menopause [1].
This medication is available under various brand names, including LYLLANA, IMVEXXY, and Estring [1]. In the past 12 months, there have been 9,125 adverse event reports associated with estradiol products [2]. The most frequently reported events in this period included issues with product or device adhesion, and reports of the drug being ineffective or used off-label [2]. Some reports also indicated that no adverse event occurred [2].
This is not medical advice. Consult a qualified healthcare professional.
Regulatory status by market
| Market | Regulator | Products | Last revision |
|---|---|---|---|
| GB United Kingdom | MHRA | 161 | May 22, 2026 |
| CA Canada | Health Canada | 32 | April 2, 2026 |
| US United States | FDA | 16 | April 23, 2026 |
GBUnited Kingdom· MHRA
161 products
Uses
Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women. The experience treating women older than 65 years is limited.
How to take
CACanada· Health Canada
32 products
Uses
Activelle® (estradiol/norethindrone acetate) is indicated for: • Treatment of moderate to severe vasomotor symptoms occurring in naturally or surgically induced estrogen deficiency states. • Treatment of vulvar or vaginal atrophy associated with menopause.
Activelle® is recommended only in women with intact uteri since the regimen includes a progestin to prevent endometrial hyperplasia. 1 Pediatrics Pediatrics (< 18 years of age): Activelle® is not indicated for use in a pediatric population.
Safety and effectiveness in pediatric patients have not been established.
How to take
USUnited States· FDA
16 products
Uses
INDICATIONS AND USAGE ESTRING is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.
How to take
Drug interactions
Known interactions involving Estradiol. Select one for details. This list is informational and not a complete interaction checker.
Showing 240 of 524. Type above to find a specific drug.
Interaction data compiled from DDInter (academic, CC-BY). Severity classification only - this is not a complete interaction checker and not medical advice.
Sources & citations
- [1]MHRA (UK) · PL044161646 · revised May 22, 2026
- [2]Health Canada (DPD) · 02249405 · revised April 24, 2025
- [3]FDA DailyMed · 110b9865-5a07-4d… · revised April 23, 2026 [PDF]
- [4]OpenFDA adverse-event reports (US), 12 months ending June 4, 2026.
Information on this page is compiled from public regulatory records. Drugvu is not affiliated with any regulator or pharmaceutical manufacturer. This is not medical advice. Always consult a qualified healthcare professional.