Epinephrine

Lidocaine 10 mg/ml (1% w/v) with Adrenaline (Epinephrine) 1:200 000 is indicated for regional anaesthesia in adults and children above 1 year of age.

Articaine Hydrochloride and Epinephrine Injection is indicated for infiltration anesthesia and nerve block anesthesia in clinical dentistry. Local or loco-regional dental anesthesia suitable for operations such as: single extractions, with no complications; multiple extractions; extractions of impacted teeth; trephinement; apical resections; removal of cysts; alveolectomies; preparation of cavity; biopulpectomies; and maxillo-facial surgery Muco-gingival operations and other surgical operations on the bone when long lasting ischaemia and analgesia are required.

1 Pediatrics Pediatrics (less than 4 years of age): Safety and effectiveness of Articaine Hydrochloride and Epinephrine Injection in pediatric patients below the age of 4 years have not been established. The use of Articaine Hydrochloride and Epinephrine Injection in children under the age of 4 years is not recommended.

175 mL/kg) in pediatric patients has not been established. [See 4 DOSAGE AND ADMINISTRATION].

1 INDICATIONS AND USAGE Epinephrine is a non-selective alpha and beta adrenergic agonist indicated: • To increase mean arterial blood pressure in adult patients with hypotension associated with septic shock. 1 ) • For emergency treatment of allergic reactions (Type 1), including anaphylaxis.

2 ) • For induction and maintenance of mydriasis during intraocular surgery. 1 Hypotension associated with Septic Shock Epinephrine Injection, 1 mg/mL is indicated to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.

2 Anaphylaxis Emergency treatment of allergic reactions (Type I), including anaphylaxis, which may result from allergic reactions to insect stings, biting insects, foods, drugs, sera, diagnostic testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

The signs and symptoms associated with anaphylaxis include flushing, apprehension, syncope, tachycardia, thready or unobtainable pulse associated with hypotension, convulsions, vomiting, diarrhea and abdominal cramps, involuntary voiding, airway swelling, laryngospasm, bronchospasm, pruritus, urticaria or angioedema, swelling of the eyelids, lips, and tongue.

EURneffy is indicated in the emergency treatment of allergic reactions (anaphylaxis) due to insect stings or bites, foods, medicinal products and other allergens as well as idiopathic or exercise induced anaphylaxis. Treatment is indicated for adults and children aged 4 years and over with a body weight of 15 kg or more.