Loading…
PHENOXYMETHYLPENICILLIN is a brand name for Amoxicillin. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Phenoxymethylpenicillin and phenoxymethylpenicillin potassium are indicated in the treatment of mild to moderately severe infections associated with micro-organisms whose susceptibility to penicillin is within the range of serum levels attained with the dosage form. Phenoxymethylpenicillin is indicated for the…
Verbatim from this product's MHRA label. Tap a section to expand.
Posology For oral administration only The dosage and frequency of Phenoxymethylpenicillin depends on the severity and localisation of the infection and expected pathogens. Phenoxymethylpenicillin Solution should be taken at least 30 minutes before or 2 hours after food, as ingestion of Phenoxymethylpenicillin with meals slightly reduces the absorption of the drug.
Phenoxymethylpenicillin 250mg is approximately equivalent to 400,000 units. g. in asplenia and in sickle cell disease): Adults and children over 12 years: 500mg every 12 hours Children 6-12 years: 250mg every 12 hours Children below 5 years: 125mg every 12 hours.
Elderly The dosage is as for adults. The dosage should be reduced if renal function is markedly impaired. Renal impairment The dosage should be reduced if renal function is markedly impaired. Hepatic impairment Dosage adjustment may be necessary in patients with impaired liver function when they also have renal failure.
In this situation the liver may be a major excretion route. 6.
The most common reactions to oral penicillin are gastrointestinal effects and hypersensitivity reactions. Although hypersensitivity reactions have been reported much less frequently after oral than after parenteral therapy, it should be remembered that all forms of hypersensitivity, including fatal anaphylaxis have been observed with oral penicillin.
Hypersensitivity reactions of all intensities - to the point of anaphylactic shock- have also been observed after oral penicillin use. Severe anaphylactoid reactions, which occur significantly less often after oral administration of penicillin than after intravenous or intramuscular administration, may necessitate appropriate emergency management.
The following convention has been utilised for the undesirable effects:- Very common (>1/10) Common (>1/100, <1/10) Uncommon (>1/1000, <1/100) Rare (>1/10,000, <1/1000) Very rare (<1/10,000) Not known (cannot be estimated from the available data).
classification of Infections and infestations Not known Pseudomembranous colitis Blood and Very rare Changes in blood counts, lymphatic disorders including, thrombocytopenia, granulocytopenia, pancytopenia, agranulocytosis neutropenia, leucopenia, eosinophilia and haemolytic anaemia.
These changes are reversible on discontinuation. Coagulation disorders have also been reported Not known Coagulation disorders (including prolongation of bleeding time and defective platelet function) Common Gastric discomfort, flatulence, nausea, vomiting, abdominal pain, diarrhoea, glossitis, stomatitis.
These disorders are usually light and abate during or at the latest after discontinuing treatment Uncommon Sore mouth and black hairy tongue (discolouration of tongue) Rare Dry mouth Gastrointestinal disorders Very Rare Superficial tooth discolouration# Very rare Hepatitis, cholestatic jaundiceHepatobiliary disorders Rare Transiently raised liver enzymes Common Allergic reactions (typically manifest as skin reactions (See Skin and subcutaneous disorders).
Penicillin should be used with caution in individuals with histories of significant allergies and/or asthma. All degrees of hypersensitivity, including fatal anaphylaxis, have been observed with oral penicillin. These reactions are more likely to occur in individuals with a history of sensitivity to penicillins, cephalosporins and other allergens.
Enquiries should be made for such a history before therapy is begun. g. adrenaline and other pressor amines, antihistamines and corticosteroids). Patients suffering from severe gastrointestinal impairments accompanied by vomiting and diarrhoea should not be treated with penicillin V, because sufficient absorption is not ensured.
g. with benzyl penicillin or another adequate antibiotic). Oral therapy should not be relied upon for patients with severe illness, or with nausea, vomiting, gastric dilation, achalasia or intestinal hypermotility. Occasionally patients do not absorb therapeutic amounts of orally administered penicillin.
Administer with caution in the presence of markedly impaired renal function, as safe dosage may be lower than the usually recommended doses. Streptococcal infections should be treated for a minimum of 10 days, and post therapy cultures should be performed to confirm the eradication of the organisms.
Prolonged use of antibiotics may result in the development of superinfection due to organisms resistant to that anti-infective including Pseudomonas and Candida. If super infection occurs, appropriate measures should be taken. In patients undergoing long-term penicillin V treatment the complete and differential blood count, as well as the liver and kidney function, should be monitored.
Severe empyema, bacteraemia, pericarditis, meningitis and arthritis should not be treated with Penicillin V during the acute phase. Patients with a past history of rheumatic fever receiving continuous prophylaxis may harbour penicillin-resistant organisms.
1 and should be used with caution in patients with known histories of allergy.
Sorbitol:
Patients with rare hereditary problems of fructose intolerance should not take this medicine.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Amoxicillin in United Kingdom.
Know a brand we are missing in United Kingdom? Suggest a brand →
Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
Urticarial, erythematous or mobilliform rash, pruritus may occur Immune disorders Very Rare Serious allergic reactions including drug fever, arthralgia, eosinophilia, angioneurotic oedema, laryngeal oedema, bronchospasm, tachycardia, dyspnoea, serum sickness, allergic vasculitis and dropping of blood pressure up to life threatening shock.
Unknown Central nervous system toxicity including convulsions (especially with high doses or in severe renal impairment); paraesthesia may occur with prolonged use, Neuropathy (usually associated with high doses of parenteral penicillin) Nervous system disorders Rare Taste alteration Very rare Interstitial nephritisRenal and urinary disorders Uncommon Nephropathy (usually associated with high doses of parenteral penicillin) Common Urticarial, erythematous or mobilliform rash and Pruritus, exanthema Skin and subcutaneous disorders Rare Exfoliative dermatitis, Toxic epidermal necrolysis, allergic vasculitis Very Rare Severe skin reactions such as Stevens- Johnson syndrome Metabolism and Nutrition Disorders Very common Loss of appetite Investigations Rare Blood pressure decreased #Superficial tooth discolouration has been reported in children.
Good oral hygiene may help to prevent tooth discolouration as it can usually be removed by brushing. Frequently fever and eosinophilia will be the only manifestations of penicillin hypersensitivity Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App store.
In these patients, the use of another prophylactic agent should be considered. Cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported with the use of penicillins. These are serious and potentially life threatening cutaneous conditions.
, progressive skin rash often with blisters or mucosal lesions) and instructed to discontinue use immediately and seek urgent medical attention. 00 mg of sorbitol in each 5 ml dose.
Sodium benzoate:
Increase in bilirubinaemia following its displacement from albumin may increase neonatal jaundice which may develop into kernicterus (non- conjugated bilirubin deposits in the brain tissue). This medicine contains 16 mg Sodium benzoate in each 5ml Dose which is equivalent to 320 mg/100 ml unit volume.