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LIOTHYRONINE SODIUM is a brand name for Liothyronine. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Used for the treatment of coma of myxoedema, the management of severe chronic thyroid deficiency and hypothyroid states occurring in the treatment of thyrotoxicosis. Liothyronine sodium can be used also in the treatment of thyrotoxicosis as an adjunct to carbimazole to prevent sub-clinical hypothyroidism developing…
Verbatim from this product's MHRA label. Tap a section to expand.
Posology Adults:
Starting dose of 10 or 20 micrograms every 8 hours, increasing after one week, if necessary, to the usual recommended daily dose of 60 micrograms in two or three divided doses. Myxoedema Coma: 60 micrograms given by stomach tube, then 20 micrograms every 8 hours.
It is more usual to start treatment with intravenous liothyronine. Adjunct to carbimazole treatment of thyrotoxicosis: 20 micrograms every 8 hours. Elderly 5 micrograms daily Paediatric population 5 micrograms daily.
Method of Administration:
Oral The tablets should be swallowed with a glass of water.
The following effects are indicative of excessive dosage and usually disappear on reduction of dosage or withdrawal of treatment for a day or two. The undesirable effects are listed below by organ class and the following frequency convention: Not known (frequency cannot be estimated from the available data) System Organ Class Frequency Adverse events Immune system disorders Not known Hypersensitivity reactions including rash, pruritus and oedema also reported.
Metabolism and nutrition disorders Not known Excessive loss of weight Psychiatric disorders Not known Restlessness, excitability, insomnia Nervous system disorders Not known Headache, tremor, Cardiac disorders Not known Anginal pain, cardiac arrhythmias, palpitations, tachycardia Vascular disorders Not known Flushing Gastrointestinal disorders Not known Diarrhoea, vomiting Skin and subcutaneous tissue disorders Not known Sweating Musculoskeletal and connective tissue disorders Not known Muscle cramps, muscular weakness General disorders and administration site conditions Not known Fever, flushing and heat intolerance Paediatric population • Transient hair loss in children (Not Known) Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
In severe and prolonged hypothyroidism, adrenocortical activity may be decreased. When thyroid replacement therapy is started, metabolism increases more than adrenocortical activity and this can lead to adrenocortical insufficiency requiring supplemental adrenocortical steroids.
Liothyronine rather than levothyroxine would be the replacement therapy of choice during block and replace treatment of thyrotoxicosis with propylthiouracil (PTU) due to the inhibition by PTU of the peripheral conversion of T4 to T3.
Liothyronine sodium treatment may result in an increase in insulin or anti-diabetic drug requirements. Care is required for patients with diabetes mellitus and diabetes insipidus. Panhypopituitarism or predisposition to adrenal insufficiency (initiate corticosteroid therapy before starting liothyronine), pregnancy, breast-feeding (see section
1. Patients with angina of effort or cardiovascular diseases and thyrotoxicosis.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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