HEPARIN SODIUM

Method of administration For routine use, 2 ml containing 200 IU of heparin should be administered into the catheter/cannula every 4-8 hours or as required.

4). Pulmonary embolism has been reported as thromboembolic complications of heparin-induced thrombocytopenia. Hypersensitivity reactions to heparin are rare. They include urticaria, conjunctivitis, rhinitis, asthma, cyanosis, tachypnoea, feeling of oppression, fever, chills, angioneurotic oedema and anaphylactic shock.

Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

v. flush solution should be used with caution in patients with hypersensitivity to low molecular weight heparin. Rigorous aseptic technique should be observed at all times in its use. As there is a risk of antibody-mediated heparin-induced thrombocytopenia, platelet counts should be measured in patients receiving regular and repeated use of heparin flush solutions for longer than 5 days (or earlier in patients with previous exposure to heparin).

Heparin treatment should be stopped immediately in those who develop thrombocytopenia or paradoxical thrombosis and heparin should immediately be eliminated from all flushes and ports. Heparin induced thrombocytopenia (HIT) and heparin induced thrombocytopenia with thrombosis (HITT) can occur up to several weeks after discontinuation of heparin therapy.

Patients presenting with thrombocytopenia or thrombosis after discontinuation of heparin should be evaluated for HIT or HITT. Repeated flushing of a catheter device with heparin may result in a systemic anticoagulant effect. This medicine contains less than 1 mmol sodium (23 mg) per 100 International Units (IU) dose, that is to say essentially ‘sodium-free’.

v. flush solution contains the preservative benzyl alcohol 10mg/ml. 3). v. flush solution contains esters of parahydroxybenzoates as a preservative system. These may cause allergic reactions (possibly delayed), and exceptionally, bronchospasm.

1. Current or history of heparin induced thrombocytopenia. Use in premature infants or neonates. Concomitant use of intravenous diclofenac.