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FUROSEMIDE is a brand name for Furosemide (also known as Frusemide). The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Furosemide is a potent diuretic with rapid action. Furosemide tablets are indicated for: 1) The treatment of fluid retention associated with heart failure, including left ventricular failure, cirrhosis of the liver and renal disease, including nephrotic syndrome. 2) The treatment of mild to moderate hypertension when…
Verbatim from this product's MHRA label. Tap a section to expand.
Adults:
The initial adult dose is 40mg daily, reduced to 20mg daily or 40mg on alternative days. In some patients daily doses of 80mg or higher (given in divided doses) may be required.
Elderly:
Caution is advised as furosemide is excreted more slowly in the elderly. 4). 3) Method of Administration: For oral administration
The frequencies are derived from literature data from studies where furosemide was used in a total of 1,387 patients, at any dose and indication. In the case where the frequency category for the same adverse reaction was different, the higher frequency category was selected.
Undesirable effects can occur with the following frequencies:
Very common (≥ 1/10), Common (≥ 1/100, < 1/10), Uncommon (≥ 1/1,000, < 1/100), Rare (≥ 1/10,000, < 1,000) and Very rare (< 1/10,000, including isolated reports) and Not Known (cannot be estimated from the available data). g. with shock).
Not known: exacerbation or activation of systemic lupus erythematosus. 3 "Contraindications"). For this reason, regular monitoring of diuresis and electrolytes and appropriate correction of any disorders is necessary.
Not known:
Dizziness, fainting and loss of consciousness (caused by symptomatic hypotension), headache. g. in nephrotic syndrome) and/or when intravenous administration of furosemide occurs very rapidly. Cases of deafness, sometimes irreversible, have been reported following oral or intravenous administration of furosemide.
Rare: tinnitus of the ears Cardiac disorders Uncommon:
Cardiac arrhythmias.
Very rare:
Furosemide may cause a reduction in blood pressure which, if pronounced may cause signs and symptoms such as impairment of concentration and reactions, light headedness, sensations of pressure in the head, headache, dizziness, drowsiness, weakness, disorders of vision, dry mouth, orthostatic intolerance.
4 "Special warnings and precautions for use") Rare: Vasculitis Not known: thrombosis Skin and subcutaneous tissue disorders Uncommon: pruritus, urticaria, rashes, bumpy dermatitis, erythema multiforme, pemphigoid, exfoliative dermatitis, purpura, photosensitivity reaction.
3) • Hypotension; • Hypovolemia; • Severe electrolyte disturbances - particularly hypokalaemia, hyponatraemia and acid-base disturbances. 2); • Difficulty with micturition including prostatic hypertrophy (increased risk of urinary retention: consider lower dose).
g. nephritic syndrome (the effect of furosemide may be impaired and its ototoxicity potentiated- cautious dose titration required); • Acute hypercalcaemia (dehydration results from vomiting and diuresis - correct before giving furosemide).
Treatment of hypercalcaemia with a high dose of furosemide results in fluid and electrolyte depletion - meticulous fluid replacement and correction of electrolyte required; • Patients who are at risk from a pronounced fall in blood pressure; • Premature infants (possible development nephrocalcinosis/nephrolithiasis; renal function must be monitored and renal ultrasonography performed); It also increases the frequency of staying open of the arterial duct and complicates neonatal respiratory distress syndrome.
• Symptomatic hypotension leading to dizziness, fainting or loss of consciousness can occur in patients treated with furosemide, particularly in the elderly, patients on other medications which can cause hypotension and patients with other medical conditions that are risks for hypotension.
Laboratory monitoring requirements: • Serum sodium Particularly in the elderly or in patients liable to electrolyte deficiency • Serum potassium The possibility of hypokalaemia should be taken into account, in particular in patients with cirrhosis of the liver, those receiving concomitant treatment with corticosteroids, those with an unbalanced diet and those who abuse laxatives.
Regular monitoring of the potassium, and if necessary treatment with a potassium supplement, is recommended in all cases, but is essential at higher doses and in patients with impaired renal function. 5). A potassium-rich diet is recommended during long-term use.
g. 4); • Severe hypokalaemia, severe hyponatraemia. 6).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Furosemide in United Kingdom.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
Not known:
Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalised flushing rash (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), lichenoid reactions Metabolism and nutrition disorders Very common: electrolyte disturbances (including symptomatic), dehydration and hypogamaemia, especially in elderly patients, increased levels of creatinine and triglycerides in the blood.
Common: hyponatraemia, hypochloraemia, hypokalaemia, increased blood cholesterol levels, increased blood uric acid levels, and gout attacks Uncommon: decrease in glucose tolerance. Latent diabetes mellitus can become manifest. See. 4 "Special warnings and precautions for use".
Not known: hypocalcaemia, hypomagnesaemia, increased blood urea levels, metabolic alkalosis, Pseudo-Bartter syndrome in the context of misuse and/or long-term use of furosemide.
General disorders and administration site conditions Uncommon:
Fatigue Rare: Fever Xanthopsia, thrombophlebitis. hyperuricemia, azotemia; Dehydration is also common, especially in the elderly and during the summer months.
Gastrointestinal disorders Uncommon:
Dry mouth, thirst, nausea, bowel motility disturbances and constipation. g. nausea, vomiting, diarrhoea), malaise may occur but not usually severe enough to necessitate withdrawal of treatment.
Rare:
Diarrhoea, vomiting Very rare: Acute Pancreatitis Renal and urinary disorders Common: increased urine volume Uncommon: Serum creatinine and urea levels can be temporarily elevated during treatment with furosemide.
Rare:
Interstitial nephritis of the urinary tubules, acute renal failure. 4 "Special warnings and precautions for use"). 4 "Special warnings and precautions for use"). 5 "Interactions with other medicinal products and other forms of interaction").
Pregnancy, puerperium and perinatal conditions In premature infants with respiratory distress syndrome, administration of Furosemide Accord Tablets in the initial weeks after birth entails an increased risk of a persistent patent ductus arteriosus.
In premature infants, furosemide can be precipitated as nephrocalcinosis/kidney stones. Rare complications may include minor psychiatric disturbances. 3) Congenital and family/genetic disorders Not known: Increased risk of remaining open in the arterial duct if furosemide is administered to premature newborns during the first weeks of life.
Reporting of suspected adverse reactions Reporting of suspected adverse reactions after the marketing authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.
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8 for details of electrolyte and metabolic abnormalities). • Renal function Frequent BUN in first few months of treatment, periodically thereafter. Long- term/high-dose BUN should regularly be measured. Marked diuresis can cause reversible impairment of kidney function in patients with renal dysfunction.
Adequate fluid intake is necessary in such patients. Serum creatinine and urea levels tend to rise during treatment. Urine excretion should be ensured. g. in patients with bladder emptying disorders, prostatic hypertrophy or urethral stenosis), increased urine excretion may cause or worsen discomfort.
Therefore, careful monitoring of patients is required, especially during the initial stages of treatment. • Glucose Adverse effect on carbohydrate metabolism - exacerbation of existing carbohydrate intolerance or diabetes mellitus. Regular monitoring of blood glucose levels is desirable.
• Other electrolytes Patients with hepatic failure/alcoholic cirrhosis are particularly at risk of hypomagnesia (as well as hypokalaemia). During long term therapy (especially at high doses) potassium, magnesium, calcium, chloride, bicarbonate and uric acid should be regularly measured.
Regular testing of creatinine and urea in the blood is also necessary. Carbohydrate metabolism must also be controlled. g. due to vomiting, diarrhoea or heavy sweating). Hypovolemia or dehydration, as well as any significant electrolyte and acid- base imbalance, should be restored.
This may require temporary discontinuation of furosemide. 8): Regular monitoring for • Blood dyscrasias. If these occur, stop furosemide immediately; • Liver damage; • Idiosyncratic reactions. Other alterations in lab values Serum cholesterol and triglyceride levels may rise during Furosemide treatment but will usually return to normal within six months.
1%, mean age 84 years, range 70-96 years) or furosemide alone […]