DIPYRIDAMOLE

Dipyridamole should usually be taken before meals. Adults: 300-600mg daily in three or four divided doses.

Children:

The normal total oral daily dose is 5mg/kg bodyweight daily in divided doses.

Elderly:

No specific information is available. Route of administration For oral administration.

Adverse effects at therapeutic doses are usually mild and transient. The following adverse reactions have been reported in patients taking dipyridamole. The adverse reactions are classified according to frequencies determined from postmarketing experience and reference literature.

Very common ≥1/10 Common ≥1/100 and <1/10 Uncommon ≥1/1000 and <1/100 Rare ≥1/10,000 and <1/1000 Very rare < 1/10,000 Not known, frequency cannot be estimated from the available data Blood and lymphatic system disorders Not known: Thrombocytopenia Immune System Disorders Not known: Angioedema, hypersensitivity reaction Nervous System Disorders Very common: Headache, dizziness Cardiac Disorders Common: Angina pectoris Not known: Tachycardia Vascular Disorders Not known: Hypotension, hot flush Respiratory, thoracic and mediastinal disorders Not known: Bronchospasm Gastrointestinal Disorders Very common: Nausea, diarrhoea Common: Vomiting Skin and Subcutaneous Tissue Disorders Common: Rash Not known: Urticaria Musculoskeletal, connective tissue and bone disorders Common: Myalgia Injury, poisoning and procedural complications Not known: Post procedural haemorrhage, operative haemorrhage.

4). Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

Among other properties, dipyridamole acts as a vasodilator. g. decompensated heart failure). Patients being treated with regular oral doses of Dipyridamole tablets should not receive additional intravenous dipyridamole. Clinical experience suggests that patients being treated with oral dipyridamole who also require pharmacological stress testing with intravenous dipyridamole, should discontinue drugs containing oral dipyridamole for twenty-four hours prior to stress testing.

5). Dipyridamole should be used with caution in patients with coagulation disorders. A small number of cases have been reported in which unconjugated dipyridamole was shown to be incorporated into gallstones to a variable extent (up to 70% by dry weight of stone).

These patients were all elderly, had evidence of ascending cholangitis and had been treated with oral dipyridamole for a number of years. There is no evidence that dipyridamole was the initiating factor in causing gallstones to form in these patients.

It is possible that bacterial deglucuronidation of conjugated dipyridamole in the bile may be the mechanism responsible for the presence of dipyridamole in gallstones. Excipients This medicine contains lactose. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.

This medicine contains sunset yellow (E110) which may cause allergic reactions including asthma. Allergy is more common in those people who are allergic to aspirin.

1.