DIPYRIDAMOLE

Posology Adults: 300-600 mg daily in three or four doses.

Paediatric population:

Dipyridamole is not recommended for children.

Elderly:

As for adults. Method of administration Dipyridamole is taken by mouth, and should usually be taken before meals.

4) Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard

g. decompensated heart failure) associated with a recently sustained myocardial infarction. Patients being treated with regular oral doses of Dipyridamole should not receive additional intravenous Dipyridamole. Clinical experience suggests that patients being treated with oral dipyridamole who also required pharmacological stress testing with intravenous dipyridamole, should discontinue drugs containing oral dipyridamole for twenty-four hours prior to stress testing.

5). A small number of cases have been reported in which unconjugated dipyridamole was shown to be incorporated into gallstones to a variable extent (upto 70% by dry weight of stone). These patients were all elderly, had evidence of ascending cholangitis and had been treated with oral dipyridamole for a number of years.

There is no evidence that dipyridamole was the initiating factor in causing gallstones to form in these patients. It is possible that bacterial deglucuronidation of conjugated dipyridamole in the bile may be the mechanism responsible for the presence of dipyridamole in gallstones.

Dipyridamole contains lactose and sucrose. Patients with rare hereditary problems of fructose intolerance, galactose intolerance, the Lapp lactase deficiency, glucose/galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.

1. Patients with known cardiac conduction difficulties or dysrhythmias