Loading…
CHLORAMPHENICOL is a brand name for Chloramphenicol. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: To be reserved for the treatment of life-threatening infections, particularly those caused by Haemophilus influenza, and typhoid fever, where other antibiotics will not suffice.
Verbatim from this product's MHRA label. Tap a section to expand.
Posology:
Adults (including the elderly): The usual dose is 500 mg every 6 hours (50 mg/kg bodyweight daily in 4 divided doses) and treatment should be continued for 2 or 3 days after the patient's temperature has returned to normal. For severe infections (meningitis, septicaemia) this dose may be doubled initially, but it must be reduced as soon as clinically practical.
Children:
Not recommended Method of administration: Oral
The most serious undesirable effects that may arise are:
Blood and lymphatic disorders (i) A reversible dose related bone marrow depression (ii) An irreversible aplastic anaemia with an estimated frequency between 1/4000 & 1/100000 Other undesirable effects (of unknown frequency) are: Blood and the lymphatic system disorders Increase in bleeding time Immune system disorders Hypersensitivity reactions including allergic skin reactions Eye disorders Optic neuritis leading to blindness Ear and labyrinth disorders Ototoxicity Vascular disorders Acidotic cardiovascular collapse Gastrointestinal disorders Nausea, vomiting, glossitis, stomatitis, diarrhoea, enterocolitis Pregnancy, puerperium and perinatal conditions “Grey” syndrome, particularly in the newborn, which appears to be related to excessively high plasma levels.
The Grey baby syndrome consists of abdominal distension, pallid cyanosis, vomiting, progressing to vasomotor collapse, irregular respiration and death within a few hours of onset of symptoms. (These symptoms are thought to be dose related and rapid clearance of chloramphenicol has been associated with recovery).
Reporting of suspected adverse reactions Reporting suspected adverse reactions after the authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard.
Dose reduction and plasma level monitoring may be required in patients with hepatic or renal impairment; in the elderly; and in patients concurrently treated with interacting drugs, see section
5) • breast-feeding mothers and during pregnancy or labour, due to a risk of foetal/infant damage (Grey Baby syndrome)
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Chloramphenicol in United Kingdom.
Know a brand we are missing in United Kingdom? Suggest a brand →
Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.