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MINIMS CHLORAMPHENICOL is a brand name for Chloramphenicol. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: Chloramphenicol is a broad spectrum bacteriostatic antibiotic. It is active against a wide variety of gram-negative and gram-positive organisms as well as rickettsiae and spirochaetes. It is indicated for use as a topical antibacterial in the treatment of superficial ocular infections. Chloramphenicol is indicated in…
Verbatim from this product's MHRA label. Tap a section to expand.
Adults (including the Elderly) One to two drops applied topically to each affected eye up to six times daily or more frequently if required. (Severe infections may require one to two drops every fifteen to twenty minutes initially, reducing the frequency of instillation gradually as the infection is controlled).
Paediatric population As for adults however dosage adjustment may be necessary in newborn infants because of reduced systemic elimination due to immature metabolism and the risk of dose-related adverse effects. The maximum duration of treatment is 10 - 14 days.
Local Sensitivity reactions such as transient irritation, burning, stinging, itching and dermatitis, may occur. Systemic Rarely, cases of major adverse haematological events (bone marrow depression, aplastic anaemia and death) have been reported following ocular use of chloramphenicol.
Pale skin, weakness, increased heart rate, out of breath, headache, pain, fever, infection, bruises may be a sign a severe blood disorder. Hypersensitivity reactions including angioedema, anaphylaxis, urticaria, vesicular and maculopapular dermatitis may also occur.
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
In severe infections topical use of chloramphenicol should be supplemented with appropriate systemic treatment. Aplastic anaemia has, rarely, followed topical use of chloramphenicol eye drops and, whilst this hazard is an uncommon one, it should be borne in mind when the benefits of the use of chloramphenicol are assessed.
Prolonged use should be avoided as it may increase the likelihood of sensitisation and the emergence of resistant organisms. Contact lenses should be removed during the period of treatment. Systemic absorption may be reduced by compressing the lacrimal sac at the medial canthus for a minute during and following the instillation of the drops.
(This blocks the passage of the drops via the naso lacrimal duct to the wide absorptive area of the nasal and pharyngeal mucosa. )
Hypersensitivity to chloramphenicol or any component of the preparation.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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