ASCORBIC ACID

Posology Adults and children over 6 years:

Prophylactic: 25 – 75 mg daily.

Note:

This unit dosage form is unsuitable for prophylactic use.

Therapeutic:

Not less than 250mg daily in divided doses. Maximum of 1000mg daily.

Children under 6 years:

This unit dosage form is unsuitable for children under 6 years.

Elderly:

As for other adults. As the dietary intake of vitamin C may be less in the elderly, they have greater risk of presenting with vitamin C deficiency. Method of administration For oral administration.

Nervous system disorders: headache. Vascular disorders: flushing. Gastrointestinal disorders: nausea, vomiting and stomach cramps. Large doses of ascorbic acid may cause diarrhoea. Skin and subcutaneous tissue disorders: redness of skin.

Renal and urinary disorders:

Patients known to be at risk of hyperoxaluria should not ingest ascorbic acid doses exceeding 1g daily as there may be increased urinary oxalate excretion. However, such risk has not been demonstrated in normal, non-hyper oxaluric individuals.

Ascorbic acid has been implicated in precipitating haemolytic anaemia in certain individuals deficient of glucose-6-phosphate dehydrogenase. Increased intake of ascorbic acid over a prolonged period may result in increased renal clearance of ascorbic acid, and deficiency may result if the intake is reduced or withdrawn rapidly.

Doses of more than 600mg daily have a diuretic effect. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.

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8). g. Labstix, Tes-Tape) and false-positive results with neocuproine methods. Estimation of uric acid by phosphotungstate or uricase with copper reduction and measurement of creatinine in non-deproteinised serum may also be affected.

High doses of ascorbic acid may give false-negative readings in faecal occult blood tests. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.

1. Ascorbic acid should not be given to patients with hyperoxaluria.