ASCORBIC ACID PASCOE

7 ml concentrate). Severe trauma or surgery can require daily dosages of at least 3 g ascorbic acid to restore normal plasma levels. 5 g ascorbic acid (50 ml concentrate) per day may be used for infusion.

Paediatric population:

The safety and efficacy of Ascorbic Acid Pascoe 150 mg/ml Concentrate for solution for injection / infusion in children and adolescents have not been established. No data are available. Method of administration For slow intravenous injection or infusion after dilution.

6. The injection/infusion therapy must be performed by a physician. The duration of use depends on the course of the illness and the results of laboratory tests.

Instructions for handling:

The vial with preservative-free concentrate for solution for injection/infusion is for single use only. It has to be used immediately after opening. Any unused solution must be discarded.

g. dyspnoea/respiratory distress. g. exanthema, urticaria, pruritus. g. dizziness, nausea, cephalgia, impaired vision) Infections and infestations: Very rare: Reactions such as chills and elevated temperature were observed in patients with acute infections.

Gastrointestinal disorders:

Very rare: Large doses may cause gastrointestinal disorders, e. g. nausea, vomiting, diarrhoea.

Renal and urinary disorders:

Very rare: Large doses may result in hyperoxaluria and renal oxalate calculi may form if the urine becomes acidic.

Very rare:

Doses of 600 mg or more daily have a diuretic action. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.

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73 m2) Patients with impaired kidney function have a higher risk of oxalate precipitation in urine due to vitamin C supplementation. g. GFR, albumin) should be done. Patients with a predisposition for the formation of renal calculi are at risk for the development of calcium oxalate stones when using high-dose vitamin C.

It is recommended not to exceed a daily vitamin C intake of 100-200 mg in patients with a history of recurrent kidney stone formation. 3 mmol (972 mg) sodium. This has to be taken into consideration by patients on a controlled sodium diet.

5 – 2 l per day). It is also recommended to avoid additional oxalate-rich foods during therapy with ascorbic acid. 5 g) of Ascorbic Acid Pascoe 150 mg/ml Concentrate for solution for injection / infusion. Lower initial doses are therefore recommended in these patients.

Note:

After the administration of gram doses, the ascorbic acid level in the urine may rise as much that the performance of tests for certain clinical-chemical parameters (glucose, uric acid, creatinine, inorganic phosphate) may be affected and the tests may yield false results.

Testing for occult blood in the feces may also yield false-negative results.

Note to be considered in the treatment of diabetic patients:

Parenterally administered ascorbic acid interferes with the blood glucose determination assay.

1. − Oxalate urolithiasis, hyperoxaluria − Iron storage disorders/iron overload (e. g. 73m2) − Glucose-6-phosphate dehydrogenase deficiency/defect