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TEVA-LIOTHYRONINE is a brand name for Liothyronine, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
Dosing Considerations Optimum dosage is usually determined by the patient’s clinical response.
Confirmatory tests include:
Radioactive Iodine T3 Resin Uptake, 131I-T3 Red cell Uptake, BMR, and the Achilles Tendon Reflex Test. Comparatively small doses (as little as 5 mcg daily) may be fully effective in some cases; however, in other instances, a satisfactory clinical response may not be achieved until recommended dosage levels have been exceeded.
Daily doses of up to 150 mcg may be required in a few resistant patients. Recommended Dose and Dosage Adjustment It is not necessary to divide daily maintenance doses. Although TEVA-LIOTHYRONINE has a rapid cut-off, its metabolic effects persist for a few days following discontinuance.
Mild Hypothyroidism:
Recommended starting dose is 25 mcg daily. 5 or 25 mcg every one or two weeks. Usual maintenance dosage is 25 – 75 mcg daily. Smaller doses may be fully effective in some patients, while 100 mcg may be required in others.
Myxedema:
Myxedematous patients are very sensitive to thyroid substances; dosage should be started at a very low level and increased gradually. Recommended starting dosage is 5 mcg daily. This may be increased by 5 or 10 mcg daily every one or two weeks.
Usual maintenance dosage is 50 to 100 mcg daily.
Cretinism:
Since the mother provides little or no thyroid hormone to the fetus, infants with thyroid dysfunction will require replacement therapy from birth. Treatment should be initiated as early as possible to avoid permanent physical and mental changes.
Recommended starting dosage is 5 mcg daily, with a 5 mcg increment every three to four days until the desired response is achieved. Infants a few months old may require only 20 mcg daily for maintenance. At one year, 50 mcg daily may be required.
Above 3 years, full adult dosage may be necessary. Simple (non-toxic) Goiter: recommended starting dosage is 5 mcg daily. This dosage may be increased by 5 to 10 mcg daily every one to two weeks. 5 or 25 mcg. Usual maintenance dosage is 75 mcg daily.
Special Populations Pediatrics:
Treatment should be initiated immediately upon diagnosis and maintained for life, unless transient hypothyroidism is suspected, in which case, therapy may be interrupted for 2 to 8 weeks after the age of 3 years to reassess the condition.
Gradual cessation of therapy is justified in patients who have maintained a normal TSH during those 2 to 8 weeks. Therapy Teva-Liothyronine Tablets Page 11 of 17 should be started with 5 mcg daily and increased only by 5 mcg increments at the recommended intervals.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Liothyronine in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
See WARNINGS AND PRECAUTIONS.
Geriatrics:
Therapy should be started with 5 mcg daily and increased only by 5 mcg increments at the recommended intervals. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
See WARNINGS AND PRECAUTIONS. Switching to TEVA-LIOTHYRONINE from thyroid, L-thyroxine or thyroglobulin medication When switching a patient to TEVA-LIOTHYRONINE from thyroid, L-thyroxine or thyroglobulin, discontinue the other medication, initiate TEVA-LIOTHYRONINE at a low dosage, and increase gradually according to the patient’s response.
When selecting a starting dose, bear in mind that this drug has a rapid onset of action, and that residual effects of the other thyroid preparation may persist for the first several weeks of therapy.
Special Instruction for T3 Suppression Test:
When 131I thyroid uptake is in the borderline-high range, administer 75-100 mcg of TEVA-LIOTHYRONINE daily for 7 days, then repeat 131I thyroid uptake test. In the hyperthyroid patient, 24-hour 131I thyroid uptake will not be affected significantly.
In the euthyroid patient, 24-hour 131I thyroid uptake will drop to less than 20%. Missed Dose The missed dose should be taken as soon as possible. If it is almost time for the next dose, the missed dose should not be taken. Instead, the next regularly scheduled dose should be taken.
Doses should not be doubled. OVERDOSAGE For management of a suspected drug overdose, contact your regional Poison Control Centre. Symptoms: see WARNINGS AND PRECAUTIONS, General and ADVERSE REACTIONS. Angina pectoris or congestive heart failure may be induced or aggravated.
Shock may also develop. Massive overdosage may result in symptoms resembling thyroid storm. Chronic excessive dosage will produce the signs and symptoms of hyperthyroidism.
Treatment:
Dosage should be reduced or therapy temporarily discontinued if signs and symptoms of overdosage appear. Treatment may be reinstituted at a lower dosage. In normal individuals, normal hypothalamic-pituitary-thyroid axis function is restored in 6 to 8 weeks after thyroid suppression.
Treatment of acute massive thyroid hormone overdosage is aimed at reducing gastrointestinal absorption of the drugs and counteracting central and peripheral effects, mainly those of increased sympathetic activity. Vomiting may be induced initially if further gastrointestinal absorption can reasonably be prevented and barring contraindications such as coma, convulsions, or loss of the gagging reflex.
Treatment is symptomatic and supportive. Oxygen may be Teva-Liothyronine Tablets Page 12 of 17 administered and ventilation maintained. Cardiac glycosides may be indicated if congestive heart failure develops. Measures to control fever, hypoglycemia, or fluid loss should be instituted if needed.
Antiadrenergic agents, particularly propranolol, have been used advantageously in the treatment of increased sympathetic activity. ACTION There are two principal naturally occurring thyroid hormones, L-tetraiodothyronine (T4, levothyroxine, L-thyroxine) and L-triiodothyronine (T3, liothyronine).
The mechanisms by which thyroid […]