SSP

SSP+ (platelet additive solution E) is a storage solution for platelet concentrates and has no pharmacological effect. The solution is not directly administered to the patient but is used to produce high quality platelets concentrates that can be stored for up to 7 days following collection at 20oC - 24oC with agitation.

See Special Handling Instructions.

Adverse Reaction Overview SSP+ (platelet additive solution E) is not expected to cause adverse events other than those normally associated with platelet transfusion. Clinical Trial Adverse Reactions No adverse reactions were reported in subjects infused with a small volume of radiolabeled platelets that had been stored for 7 days in 70% SSP+/30% plasma Platelet Additive Solution.

SSP+ Product Monograph Draft:

September 12, 2018 Page 6 of 16

SSP+ (platelet additive solution E) is NOT FOR DIRECT INTRAVENOUS INFUSION  Multiple transfusions of SSP+-stored platelets may lead to overdosage of potassium and magnesium  Check the integrity of the container and the overwrap before use.

 Use at a temperature between 18° and 24°C.  Store at a temperature between 15°C and 30°C.  Do not use sharp objects.  Do not use if the overwrap or the container show any visible signs of deterioration.  Do not use if the solution is cloudy.

 Do not vent for the transfusion of platelets.  Must be used with approved devices including connections.  Do not re-use. Discard unused SSP+ solution.  Do not use if no label.

SSP+ (platelet additive solution E) alone is not for direct intravenous infusion. There are no known contraindications associated with the use of SSP+ solution for the preparation of platelet concentrates.