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MUSCLE & JOINT is a brand name for Ibuprofen, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: AND CLINICAL USE ........................................................................ 3 CONTRAINDICATIONS ............................................................................................ 3 WARNINGS AND PRECAUTIONS............................................................................ 4 ADVERSE…
Verbatim from this product's HC label. Tap a section to expand.
Dosing Considerations Do not take for fever for more than 3 days or for pain for more than 5 days unless directed by a physician. The safety issues to consider when developing a dosage regimen of ibuprofen for individual patients are applicable to: Elderly patients older than 65 years who are frail or debilitated and consideration should be given to a starting dose lower than the one usually recommended (See WARNINGS AND PRECAUTIONS, Elderly).
Recommended Dose and Dosage Adjustment Adults and children over 12:
Take 1 caplet by mouth every six to eight hours as needed. Do not exceed 3 caplets in 24 hours, unless directed by a physician. Missed Dose Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take your medicine and skip your missed dose.
Do not take two doses at the same time. Administrations See Recommended Dose and Dosage Adjustment. OVERDOSAGE Symptoms of Overdose102-104 The toxicity of ibuprofen overdose is dependent upon the amount of drug ingested and the time elapsed since ingestion; individual responses may vary, thus making it necessary to evaluate each case separately.
Although uncommon, serious toxicity and death have been reported with ibuprofen overdosage. The most frequently reported symptoms of ibuprofen overdose include abdominal pain, nausea, vomiting, lethargy and drowsiness. Other CNS symptoms include headache, tinnitus, CNS depression and seizures.
Metabolic acidosis, coma, acute renal failure and apnoea (primarily in very young pediatric patients) may rarely occur. Cardiovascular toxicity, including hypotension, bradycardia, tachycardia and atrial fibrillation, have also been reported.
Treatment of Overdose In cases of acute overdose, the stomach should be emptied through induction of emesis (in alert patients only) or gastric lavage. Emesis is most effective if initiated within 30 minutes of ingestion. Orally administered activated charcoal may help in reducing the absorption of ibuprofen when given less than 2 hours following ingestion.
112 Inducing diuresis may be helpful. The treatment of acute overdose is primarily supportive. Management of hypotension, acidosis and gastrointestinal bleeding may be necessary. In pediatric patients, the estimated amount of ibuprofen ingested per body weight may be helpful to predict the potential for development of toxicity although each case must be evaluated.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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Ingestion of less than 100 mg/kg is unlikely to produce toxicity. Pediatric patients ingesting 100 to 200 mg/kg may be managed with induced emesis and a minimal observation time of at least four hours. Pediatric patients ingesting 200 to 400 mg/kg of ibuprofen should have immediate gastric emptying and at least four hours observation.
Pediatric patients ingesting greater than 400 mg/kg require immediate medical referral, careful observation and appropriate supportive therapy. Induced emesis is not recommended in overdoses greater than 400 mg/kg because of the risk for convulsions and the potential for aspiration of gastric contents.
In adult patients, the dose reportedly ingested does not appear to be predictive of toxicity. The need for referral and follow-up must be judged by the circumstances at the time of the overdose ingestion. Symptomatic adults should be carefully evaluated, observed and supported.
For management of a suspected drug overdose, contact your regional Poison Control Centre. 1 He required dialysis for several months, at which point his renal function improved. In children, ibuprofen overdoses less than 100 mg/kg are unlikely to produce toxicity.
In adults, the dose of ibuprofen reportedly ingested does not appear to be predictive of toxicity. 4 He was treated with gastric lavage, charcoal, and various supportive measures and recovered within 24 hours. 2 Page 21 of 44 Prostaglandins are naturally-occurring fatty acid derivatives that are widely distributed in the tissues.
They are believed to be a common factor in the production of pain, fever, and inflammation. Prostaglandins are believed to sensitize tissues to pain- and inflammation- producing mediators such as histamine, 5-hydroxytryptamine, and kinins.
The enzyme catalysing the committed step in prostaglandin biosynthesis is prostaglandin endoperoxide synthase, also known as cyclooxygenase. 3 Other pharmacologic effects such as lysosome and plasma membrane stabilisation have been observed, but the potential relevance of these effects to ibuprofen-induced analgesia and antipyresis is unclear.
A recent study confirmed that ibuprofen 400 mg provided a significantly faster onset of relief as measured by first perceptible relief, meaningful relief, percent attaining complete relief, and superior […]