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MICRO ZN is a brand name for Zinc, supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Verbatim from this product's HC label. Tap a section to expand.
No adverse reactions have been reported for the amount of zinc present in this product. The amount is small and toxicity symptoms are not likely to occur at the suggested dosage level. OVERDOSAGE Zinc is a relatively nontoxic compound, but toxicity can occur by oral administration , inhalation and hemodialysis.
Ingestion of excess zinc has usually resulted from storage of food or beverages in galvanized containers, which results in diarrhea, vomiting and fever. One report of intoxication following inhalation of zinc oxide fumes causing fever, headache and vomiting has been reported in the literature.
In 1972, a case of zinc poisoning was reported in a patient on hemodialysis with zinc-contaminated water. The patient developed nausea, fever and severe anemia. Infusions of 40 to 80 mg/day of zinc have been used with no apparent ill effects.
No adverse effects were reported when a group of 22 patients received a 20 mg infu sion before and after surgery. One case of ill effects was reported when a daily 10 mg dose of zinc was infused over one hour for 5 days. The ill effects were tachycardia, hypothermia, profuse sweating and blurred vision.
One death resulted from an overdose of intravenous zinc which was due to a local prescribing error. 4 g) of zinc sulfate infused over a 60-hour period. Analysis of her serum zinc showed a zinc level of 4184 mcg/100 mL. Clinical manifestations were edema, jaundice, vomiting, diarrhea and oliguria.
Seven patients who received an accidental overdosage (25 mg zinc/litre TPN solution; equivalent to 50 to 70 mg zinc/day) exhibited hyperamylasemia (557 to 1850 Klein Units; normal 130 to 310). For management of a suspected drug overdose, contact your regional Poison Control Centre immediately.
5 to 4 mg of zinc per day. Micro Zn Page 5 of 7 For acute catabolic states an additional 2 mg of zinc per day is suggested. 1 mg of zinc per kg of stool or ileostomy output is recommended. Pediatrics For full-term infants and children up to 5 years of age, 100 mcg zinc/kg/day is recommended.
For premature infants weighing up to 3 kg in body weight, 300 mcg zinc/kg/day is recommended. Administration Routine monitoring of zinc plasma levels is suggested as a guideline for administration. Normal plasma levels for zinc vary from approximately 68 to 136 mcg per 100 mL.
Frequently monitor the blood zinc levels for those patients receiving more than the usual maintenance dosage level of zinc. Micro Zn is for intravenous use after dilution only. 5 Description: Zinc sulfate is an odourless, colourless, transparent, efflorescent crystals or white crystalline powder with an astringent metallic taste freely soluble in water.
50 mmol (7 mEq) of zinc. Zinc sulfate 220 mg is approximately equivalent to 50 mg of zinc. Dilution for Intravenous Use Aseptic addition of Micro Zn to the amino acid/dextrose component of a TPN solution under a laminar flow hood is recommended.
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Zinc in Canada.
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Brand names are compiled from public regulatory records for active-ingredient mapping only. Drugvu is not affiliated with any manufacturer. This is not medical advice.
After dilution, the solution must be used within 24 hours. Visually inspect parenteral drug products for particulate matter and discolouration prior to administration whenever container and solution permit. s. s. Sulfuric acid is used to adjust the pH.
Micro Zn (Zinc Sulfate Injection USP) is available in two strengths, 1 mg/mL and 5 mg/mL of zinc, in single use vials of 10 mL, boxes of 10. STORAGE AND STABILITY Store between 15 and 28ºC. Protect from freezing. The chlorobutyl rubber stopper is not made with natural rubber latex.
Micro Zn Page 7 of 7 REFERENCES 1. Boddapati S, Yang K and Murty R. Intravenous solution compatibility and filter-retention characteristics of trace element preparations. Am J Hosp Pharm 1981; 38:1731 -1736. 2. Ellenhorn MJ and Barceloux, eds.
Medical Toxicology. Diagnosis and Treatment of Human Poisoning. Elsevier Science Publishing Co. , New York, 1988; 1064 -1065. 3. Expert Panel, AMA Department of Food and Nutrition. Guidelines for essential trace element preparations for parenteral use.
JAMA 1979; 241: 2051 -2054. 4. Phillips GD and Odgers CL.
Parenteral Nutrition:
Current status and concepts. Drug 1982; 23: 276-323. 5. Report of a WHO expert group on trace elements in human nutrition. 3 Zinc Tech. Rep. Ser. Wed. Hlth. Org. No. 532, 1973; 9-14. 6. Reynolds JE ed. Martindale. The Extra Pharmacopeia. The Pharmaceutical Press, London 1982; 943-946.
7. Tasman-Jones C, Kay RG and Lee SP. Zinc and copper defiency, with particular reference to parenteral nutrition. Surg. Annu 1978, 10: 23-52. 8. Underwood EJ. Trace Elements in Human and Animal Nutrition. 4th ed. New Academic Press 1977; 196-242.
9. Wolman SL, Anderson GH, Marliss EB and Jeejeebhoy KN. Zinc in total parenteral nutrition: requirements and metabolic effects. Gastroenterology 19. 10. Zlotkin SH. Total parenteral nutrition in children. Pediatr Clin North Am, 1985; 32(2):381 - 400.
11. Brocks A, Reid H, Glazer G. Acute intravenous zinc poisoning. Br Med J, 1977; May 28;1(6073):1390-1.