MICRO+6 CONCENTRATE

5 to 5 mg of zinc per day. For acute catabolic states an additional 2 mg of zinc per day is suggested. 1 mg of zinc per kg of stool or ileostomy output is recommended. Pediatrics For full-term infants, 50 to 250 mcg zinc/kg/day and children 50 mcg zinc/kg/day are recommended.

For premature infants weighing up to 3 kg in body weight, 400 mcg zinc/kg/day is recommended. 5 mg copper per day. Pediatrics For premature infants < 3kg, infants and children the suggested dosage level is 20 mcg copper per kg daily.

Manganese Adults For the metabolically stable adult receiving TPN, 55 mcg/day is suggested as the additive dosage level for manganese. Pediatrics A dosage level of 1 mcg/kg/day with a maximum daily total dose of 15 mcg of manganese is recommended.

Chromium Adults For the metabolically stable adult receiving TPN, 10 to 15 mcg of chromium per day is suggested as the additive dosage level. Micro+ 6 Page 13 of 18 The metabolically stable adult with intestinal fluid loss may require 20 mcg of chromium daily with frequent monitoring of blood levels as a guideline for subsequent administration.

2 mcg chromium/kg/day are recommended as the additive dosage level. Selenium Adults For the metabolically stable adult receiving TPN, the suggested additive dosage level is 60 to 100 mcg selenium per day. Pediatrics For premature infants < 3kg, the suggested selenium level is 2 to 3 mcg/kg/day.

For infants and children, the suggested dosage level is 2 mcg selenium per kg per day. Iodine For adults who are metabolically stable, the recommended dosage level is 1 to 2 mcg iodine/kg/day. For normal adults this would be 75-150 mcg/day.

For pregnant or lactating mothers, and growing children, the recommended dosage level is 2 to 3 mcg iodine/kg/day. For premature infants < 3kg, infants and children, the recommended dosage is 1 mcg iodine/kg/day. Administration Routine monitoring of zinc, copper, manganese, chromium, selenium and iodine plasma levels is suggested as a guideline for administration.

For iodine, routine monitoring of thyroid function is also indicated. Zinc Normal plasma levels vary from approximately 68 to 136 mcg per 100 mL. Frequently monitor the blood zinc levels for those patients receiving more than the usual maintenance dosage level of zinc.

Copper While the normal adult plasma levels range from 90 to 130 mcg/100 mL, the normal full- term newborn’s serum levels are about one-third of this. These values were found to rise gradually during the first week of life, fall to below adult levels at two months of age, rise to within the adult range at three months of age, and to rise still higher above the adult range at eight months of age, at which levels the values persisted throughout the remainder of infancy.

Micro+ 6 Page 14 of 18 Manganese Manganese is bound in both the serum and the erythrocytes. Normal human blood values have been recognized as 6 to 10 mcg/mL. Chromium Changes in serum chromium following glucose loading or insulin injection should be regarded with caution as indicators of chromium status.