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LISINOPRIL/HCTZ (TYPE Z) is a brand name for Lisinopril, supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: LISINOPRIL/HCTZ (TYPE Z) (lisinopril and hydrochlorothiazide tablets) is indicated for: The treatment of essential hypertension in patients for whom combination therapy is appropriate. LISINOPRIL/HCTZ (TYPE Z) is not indicated for initial therapy (see 4 DOSAGE AND ADMINISTRATION). Patients in whom lisinopril and…
Verbatim from this product's HC label. Tap a section to expand.
). Patients in whom lisinopril and diuretic are initiated simultaneously can develop symptomatic hypotension (see 9 DRUG INTERACTIONS). LISINOPRIL/HCTZ (TYPE Z) is not indicated for the treatment of renovascular hypertension (see 7 WARNINGS AND PRECAUTIONS, Hypotension).
3 Pediatrics). 4 Geriatrics). 2 CONTRAINDICATIONS LISINOPRIL/HCTZ (TYPE Z) is contraindicated in: Patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.
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4 Drug-Drug Interactions) 3 SERIOUS WARNINGS AND PRECAUTIONS BOX Serious Warnings and Precautions When used in pregnancy, ACE inhibitors can cause injury or even death of the developing fetus. 1 Pregnant Women). 1 Dosing Considerations Dosage must be individualized.
The fixed combination is not for initial therapy. The dose of LISINOPRIL/HCTZ (TYPE Z) should be determined by the titration of the individual components. Patients usually do not require doses in excess of 50 mg of hydrochlorothiazide daily, particularly when combined with antihypertensive agents.
2 Recommended Dose and Dosage Adjustment Patients should be titrated on the individual drugs. If the fixed combination represents the dosage determined by this titration, the use of LISINOPRIL/HCTZ (TYPE Z) may be more convenient in the management of patients.
If during maintenance therapy dosage adjustment is necessary, it is advisable to use individual drugs. 5 mg or 20/25 mg tablets once daily may be substituted if the titrated doses are the same as those in the fixed combination (see 1 INDICATIONS and 7 WARNINGS AND PRECAUTIONS).
LISINOPRIL/HCTZ Page 6 of 61 Lisinopril monotherapy For lisinopril monotherapy the recommended initial dose in patients not on diuretics is 10 mg of lisinopril once a day. Dosage should be adjusted according to blood pressure response.
The usual dosage range of lisinopril is 10 to 40 mg administered in a single daily dose. The antihypertensive effect may diminish toward the end of the dosing interval regardless of the administered dose, but most commonly with a dose of 10 mg daily.
This can be evaluated by measuring blood pressure just prior to dosing to determine whether satisfactory control is being maintained for 24 hours. If it is not, an increase in dose should be considered. The maximum dose used in long-term controlled clinical trials was 80 mg/day.
, Hypotension). 3 Pediatrics). 4 Geriatrics). 2 CONTRAINDICATIONS LISINOPRIL/HCTZ (TYPE Z) is contraindicated in: Patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.
1 Pregnant Women and
LISINOPRIL/HCTZ (TYPE Z) is contraindicated in: Patients who are hypersensitive to this drug or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container. 4 Drug-Drug Interactions)
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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If blood pressure is not controlled with lisinopril alone, a low dose of a diuretic may be added. 5 mg has been shown to provide an additive effect. After the addition of a diuretic, it may be possible to reduce the dose of lisinopril.
Diuretic Treated Patients In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally may occur following the initial dose of lisinopril. The diuretic should, if possible, be discontinued for two to three days before beginning therapy with lisinopril to reduce the likelihood of hypotension (see 7 WARNINGS AND PRECAUTIONS, Cardiovascular).
The dosage of lisinopril should be adjusted according to blood pressure response. If the patient's blood pressure is not controlled with lisinopril alone, diuretic therapy may be resumed as described above. If the diuretic cannot be discontinued, an initial dose of 5 mg of lisinopril alone should be administered and the patient remain under medical supervision for at least two hours, and until blood pressure has stabilized for at least an additional hour (see 7 WARNINGS AND PRECAUTIONS, Cardiovascular and