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LASIX SPECIAL is a brand name for Furosemide (also known as Frusemide), supplied as a tablet. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: LASIX® SPECIAL (furosemide) is indicated: as an adjuvant treatment of oliguria in the promotion of diuresis in the treatment of edema in selected patients with: acute renal failure, e.g. in the postoperative phase and in association with septic infections; chronic renal failure with fluid retention, both in…
Verbatim from this product's HC label. Tap a section to expand.
). 1 Pediatrics Pediatrics (Newborn to 15 years) LASIX SPECIAL is not recommended for the pediatric population (see 2 CONTRAINDICATIONS, 7 WARNINGS AND PRECAUTIONS, Special Populations, Pediatrics). 2 Geriatrics Geriatrics (> 61 years of age) Use in the geriatric population is associated with differences in safety.
Dose selection for the elderly patients should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and the concomitant disease or other drug therapy. (see 7 WARNINGS AND PRECAUTIONS). 2 CONTRAINDICATIONS LASIX SPECIAL is contraindicated in: Patients who are hypersensitive to furosemide, sulfonamide -derived drugs, or to any ingredient in the formulation or component of the container.
For a complete listing, see
). Patients with severe dehydration, hypotension, hyponatremia, hypokalemia or hypovolemia (see 7 WARNINGS AND PRECAUTIONS and 8 ADVERSE REACTIONS). Children (Newborn -15 years) Women that are breastfeeding (see 7 WARNINGS AND PRECAUTIONS).
3 SERIOUS WARNINGS AND PRECAUTIONS Serious Warnings and Precautions LASIX SPECIAL is a potent diuretic which, if given in excessive amounts, can lead to profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose and dosage schedule have to be adjusted to the individual patient's needs (see Dosage and Administration).
The use of furosemide has been associated with exacerbation or activation of systemic lupus erythematosus. 1 Dosing Considerations LASIX SPECIAL is to be used under strict medical supervision in a hospital setting. THE HIGH-DOSAGE FORMULATION LASIX SPECIAL IS INTENDED EXCLUSIVELY FOR SELECTED PATIENTS WITH SEVERELY IMPAIRED GLOMERULAR FILTRATION (GFR of less than 20 mL/min.
), WHO HAVE NOT RESPONDED TO CONVENTIONAL DOSES OF FUROSEMIDE When LASIX SPECIAL is used in high doses, careful attention much be paid to the following: ● If the patient is in shock, hypovolemia and hypotension must be corrected by appropriate measures before starting therapy.
LASIX SPECIAL Furosemide tablets Page 6 of 37 ● Any serious abnormalities of serum electrolytes or acid-base balance must be corrected before starting therapy ● When treating patients with conditions likely to interfere with micturition, such as prostatic hypertrophy or disturbed consciousness, it is absolutely essential to ensure free urinary drainage.
● Because of the wide and unpredictable individual variations in responsiveness, it is important to adjust dosage and route of administration to individual needs. ● Once the desired rise in urinary output has begun, exact balance of water intake and water output must be maintained throughout the course of treatment, so as to avoid hypovolemia or hypotension.
, General) Kimmelstiel-Wilson syndrome. LASIX® SPECIAL (furosemide 500 mg) IS A HIGH-DOSAGE FORMULATION OF FUROSEMIDE AND IS INTENDED EXCLUSIVELY FOR PATIENTS WITH SEVERELY IMPAIRED RENAL FUNCTION. LASIX SPECIAL IS TO BE USED UNDER STRICT MEDICAL SUPERVISION IN A HOSPITAL SETTING ( see 4 DOSAGE AND ADMINISTRATION).
1 Pediatrics Pediatrics (Newborn to 15 years) LASIX SPECIAL is not recommended for the pediatric population (see 2 CONTRAINDICATIONS, 7 WARNINGS AND PRECAUTIONS, Special Populations, Pediatrics). 2 Geriatrics Geriatrics (> 61 years of age) Use in the geriatric population is associated with differences in safety.
Dose selection for the elderly patients should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and the concomitant disease or other drug therapy. (see 7 WARNINGS AND PRECAUTIONS). 2 CONTRAINDICATIONS LASIX SPECIAL is contraindicated in: Patients who are hypersensitive to furosemide, sulfonamide -derived drugs, or to any ingredient in the formulation or component of the container.
g. sulfonamide antibiotics or sulfonylureas) may show cross-sensitivity to furosemide. Patients with complete renal shutdown and glomerular filtration rate below 5 mL/min. Patients whose glomerular filtration rate is above 20 mL/min.
In such cases, it might cause extremely severe water and electrolyte losses Patients with hepatic cirrhosis, patients with renal failure due to poisoning with nephrotoxic or hepatotoxic substances and patients with renal failure accompanied by hepatic coma and precoma (see 7 WARNINGS AND PRECAUTIONS and
, 7 WARNINGS AND PRECAUTIONS, Special Populations, Pediatrics). 2 Geriatrics Geriatrics (> 61 years of age) Use in the geriatric population is associated with differences in safety. Dose selection for the elderly patients should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and the concomitant disease or other drug therapy.
(see 7 WARNINGS AND PRECAUTIONS). 2 CONTRAINDICATIONS LASIX SPECIAL is contraindicated in: Patients who are hypersensitive to furosemide, sulfonamide -derived drugs, or to any ingredient in the formulation or component of the container.
g. sulfonamide antibiotics or sulfonylureas) may show cross-sensitivity to furosemide. Patients with complete renal shutdown and glomerular filtration rate below 5 mL/min. Patients whose glomerular filtration rate is above 20 mL/min.
In such cases, it might cause extremely severe water and electrolyte losses Patients with hepatic cirrhosis, patients with renal failure due to poisoning with nephrotoxic or hepatotoxic substances and patients with renal failure accompanied by hepatic coma and precoma (see 7 WARNINGS AND PRECAUTIONS and 8 ADVERSE REACTIONS).
Patients with severe dehydration, hypotension, hyponatremia, hypokalemia or hypovolemia (see 7 WARNINGS AND PRECAUTIONS and 8 ADVERSE REACTIONS). Children (Newborn -15 years) Women that are breastfeeding (see 7 WARNINGS AND PRECAUTIONS).
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
Other brands of Furosemide in Canada.
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Careful electrolyte replacement is also necessary. The dosage of high strength LASIX SPECIAL given below is for adults only. The administration of large doses of furosemide in children has been associated with permanent deafness (See 7 WARNINGS AND PRECAUTIONS).
2 Recommended Dose and Dosage Adjustment The dose used must be the lowest that is sufficient to achieve the desired effect. g. 80-160 mg/day. If conventional doses fail to produce an adequate diuresis, a single dose of 250 mg may be given as a starting dose.
If a satisfactory diuresis does not ensue within 4-6 hours, the initial dose may be doubled to 500 mg. The maximum daily dose of LASIX SPECIAL is 1000 mg and this should not be exceeded. 5 litres per day. 5 OVERDOSAGE Symptoms Dehydration, electrolyte depletion and hypotension may be caused by overdosage or accidental ingestion.
In cirrhotic patients, overdosage might precipitate hepatic coma. g. hypovolemia, dehydration, hemoconcentration, cardiac arrhythmias (including A-V block and ventricular fibrillation). Symptoms of these disturbances include severe hypotension (progressing to shock), acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion.
For management of a suspected drug overdose, contact your regional poison control centre. Treatment The drug should be discontinued and appropriate corrective treatment applied: replacement of excessive fluid and electrolyte losses; serum electrolytes, carbon dioxide level and blood LASIX SPECIAL Furosemide tablets Page 7 of 37 pressure should be determined frequently.
Adequate drainage must be assured in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy). No specific antidote to furosemide is known. g. activated charcoal). 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING Table 1 – Dosage Forms, Strengths, Composition and Packaging Tablets, 500 mg: Yellow, round, one side double-scored.
On the scored side, are debossed the letters “D”, “L”, “X” between the score lines. Other side of the tablet is debossed with the Hoechst “Tower and Bridge” logo. Each tablet contains 500 mg furosemide in HDPE bottle s of 20. 7 WARNINGS AND PRECAUTIONS General All patients receiving LASIX SPECIAL therapy should be observed for signs and symptoms of fluid or electrolyte imbalance, hyponatremia, hypochloremic alkalosis, hypovolemia, hypomagnesemia, or hypocalcemia: dryness of the mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oligourea, tachycardia, arrhythmia, or gastro-intestinal disturbances such as nausea and vomiting, increases in blood glucose and alteration in glucose tolerance tests.
During long-term therapy, a high-potassium diet is recommended. Potassium supplements may be required especially when high doses are used for prolonged periods. g. g. digitalis preparations and drugs inducing QT interval prolongation syndrome).
Particular caution with potassium levels is necessary when the patient is on digitalis glycosides or potassium-depleting steroids. Potassium supplementation, diminution in dose, or discontinuation of LASIX SPECIAL therapy may be required.
Since rigid sodium restriction is conducive to both hyponatremia and hypokalemia, strict restriction in sodium intake is not advisable in patients receiving LASIX SPECIAL therapy. […]