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LASIX is a brand name for Furosemide (also known as Frusemide), supplied as a solution. The medicine, its uses, side effects and dosage are the same regardless of brand.
Used for: LASIX ORAL SOLUTION® (furosemide) is indicated for: The treatment of edema associated with congestive heart failure, cirrhosis of the liver and renal disease including, nephrotic syndrome, as well as other edematous states amenable to diuretic therapy. The control of mild to moderate hypertension, used alone, or…
Verbatim from this product's HC label. Tap a section to expand.
). The available pediatric data does not allow for a recommendation of a specific age range in this population. 2 Geriatrics Geriatrics (> 65 years of age) Use in the geriatric population is associated with differences in safety. Dose selection for the elderly patients should be cautious, usually starting at the low end of dosage range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and the concomitant disease or other drug therapy.
(see 7 WARNINGS AND PRECAUTIONS). 2 CONTRAINDICATIONS LASIX ORAL SOLUTION (furosemide) is contraindicated in: Patients who are hypersensitive to furosemide, sulfonamide -derived drugs or to any ingredient in the formulation or component of the container.
For a complete listing, see 4 DOSAGE AND ADMINISTRATION of the product monograph. g. sulfonamide antibiotics or sulfonylureas) may show cross-sensitivity to furosemide. Patients with complete renal shutdown. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, the drug should be discontinued.
LASIX ORAL SOLUTION (furosemide) Page 5 of 40 Patients with hepatic coma and pre-coma or in states of electrolyte depletion until the basic condition is improved or corrected. Therapy with LASIX ORAL SOLUTION should not be initiated in these patients (see 7 WARNINGS AND PRECAUTIONS, Hepatic/Biliary/Pancreatic).
Patients with severe dehydration, hypotension, hyponatremia, hypokalemia, or hypovolemia (see 7 WARNINGS AND PRECAUTIONS and 8 ADVERSE REACTIONS). g. ) as furosemide may be capable of displacing bilirubin from albumin at least "in vitro".
It can lead to hyperbilirubinemia and possibly kernicterus. Women that are breast-feeding (see 7 WARNINGS AND PRECAUTIONS). 3 SERIOUS WARNINGS AND PRECAUTIONS BOX Serious Warnings and Precautions LASIX ORAL SOLUTION is a potent diuretic which, if given in excessive amounts, can lead to profound diuresis with water and electrolyte depletion.
Therefore, careful medical supervision is required and dose and dosage schedule have to be adjusted to the individual patient's needs (see 4 Dosage and Administration). The use of LASIX ORAL SOLUTION has been associated with exacerbation or activation of systemic lupus erythematosus.
1 Dosing Considerations Careful observations for changes in blood pressure must be made when LASIX ORAL SOLUTION is used with other antihypertensive drugs, especially during initial therapy. The dosage of other agents must be reduced by at least 50% as soon as LASIX ORAL SOLUTION is added to the regimen to prevent excessive drop in blood pressure.
). g. ) as furosemide may be capable of displacing bilirubin from albumin at least "in vitro". It can lead to hyperbilirubinemia and possibly kernicterus. Women that are breast-feeding (see 7 WARNINGS AND PRECAUTIONS). 3 SERIOUS WARNINGS AND PRECAUTIONS BOX Serious Warnings and Precautions LASIX ORAL SOLUTION is a potent diuretic which, if given in excessive amounts, can lead to profound diuresis with water and electrolyte depletion.
Therefore, careful medical supervision is required and dose and dosage schedule have to be adjusted to the individual patient's needs (see 4 Dosage and Administration). The use of LASIX ORAL SOLUTION has been associated with exacerbation or activation of systemic lupus erythematosus.
1 Dosing Considerations Careful observations for changes in blood pressure must be made when LASIX ORAL SOLUTION is used with other antihypertensive drugs, especially during initial therapy. The dosage of other agents must be reduced by at least 50% as soon as LASIX ORAL SOLUTION is added to the regimen to prevent excessive drop in blood pressure.
As the blood pressure falls under the potentiating effect of LASIX ORAL SOLUTION, a further reduction in dosage or even discontinuation of other antihypertensive drugs may be necessary. 2 Recommended Dose and Dosage Adjustment Adults Edema The usual initial dose of LASIX ORAL SOLUTION is 4 mL to 8 mL of 10 mg/mL.
Ordinarily, a prompt diuresis ensues and the starting dose can then be maintained or even reduced. If a satisfactory diuresis has not occurred within 6 hours, succeeding doses should be increased by increments of 2 mL to 4 mL of 10 mg/mL if necessary.
Maximum daily dose: 20 mL of 10 mg/mL. Once the effective single dose has been determined, it may be repeated 1 to 3 times a day. LASIX ORAL SOLUTION (furosemide) Page 6 of 40 The mobilization of edema may be most efficiently and safely accomplished by utilizing an intermittent dosage schedule in which LASIX ORAL SOLUTION is given for 2 to 4 consecutive days each week.
). 2 CONTRAINDICATIONS LASIX ORAL SOLUTION (furosemide) is contraindicated in: Patients who are hypersensitive to furosemide, sulfonamide -derived drugs or to any ingredient in the formulation or component of the container. For a complete listing, see 4 DOSAGE AND ADMINISTRATION of the product monograph.
g. sulfonamide antibiotics or sulfonylureas) may show cross-sensitivity to furosemide. Patients with complete renal shutdown. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, the drug should be discontinued.
LASIX ORAL SOLUTION (furosemide) Page 5 of 40 Patients with hepatic coma and pre-coma or in states of electrolyte depletion until the basic condition is improved or corrected. Therapy with LASIX ORAL SOLUTION should not be initiated in these patients (see 7 WARNINGS AND PRECAUTIONS, Hepatic/Biliary/Pancreatic).
Patients with severe dehydration, hypotension, hyponatremia, hypokalemia, or hypovolemia (see 7 WARNINGS AND PRECAUTIONS and
LASIX ORAL SOLUTION (furosemide) is contraindicated in: Patients who are hypersensitive to furosemide, sulfonamide -derived drugs or to any ingredient in the formulation or component of the container. For a complete listing, see
Not medical advice. Always read the patient information leaflet and follow your prescriber or pharmacist.
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As the blood pressure falls under the potentiating effect of LASIX ORAL SOLUTION, a further reduction in dosage or even discontinuation of other antihypertensive drugs may be necessary. 2 Recommended Dose and Dosage Adjustment Adults Edema The usual initial dose of LASIX ORAL SOLUTION is 4 mL to 8 mL of 10 mg/mL.
Ordinarily, a prompt diuresis ensues and the starting dose can then be maintained or even reduced. If a satisfactory diuresis has not occurred within 6 hours, succeeding doses should be increased by increments of 2 mL to 4 mL of 10 mg/mL if necessary.
Maximum daily dose: 20 mL of 10 mg/mL. Once the effective single dose has been determined, it may be repeated 1 to 3 times a day. LASIX ORAL SOLUTION (furosemide) Page 6 of 40 The mobilization of edema may be most efficiently and safely accomplished by utilizing an intermittent dosage schedule in which LASIX ORAL SOLUTION is given for 2 to 4 consecutive days each week.
With doses exceeding 12 mL/day of 10 mg/mL, careful clinical and laboratory observations are particularly advisable. Hypertension A dosage schedule of 2 mL to 4 mL of 10 mg/mL twice daily is recommended. Individualized therapy is of great importance.
It is further recommended, if 4 mL twice daily of 10 mg/mL does not lead to a clinically satisfactory response, other antihypertensive agents should be added, rather than increase the dose of LASIX ORAL SOLUTION. Pediatrics LASIX ORAL SOLUTION therapy should be instituted in the hospital, in carefully selected patients, under close observation with frequent monitoring of serum electrolytes.
0 mg/kg body weight. The total daily dose (given in divided doses of 6 to 12 hours apart) should not exceed 2 mg/kg orally. In the newborn and in premature babies, the daily dose should not exceed 1 mg/kg. An intermittent dosage schedule should be adopted as soon as possible using th e minimum effective dose at the longest possible intervals.
Particular caution with regard to potassium levels is always desirable when LASIX ORAL SOLUTION is used in infants and children. 5 Missed dose In case of a missed dose, patients may not notice any symptoms of the condition for which they are being treated for.
However, please advise your patients to take the missed dose as soon as possible. And if it is almost time for their next dose, skip the missed dose and take the dose which is due as per the regular dosing schedule. Do not double dose.
With doses exceeding 12 mL/day of 10 mg/mL, careful clinical and laboratory observations are particularly advisable. Hypertension A dosage schedule of 2 mL to 4 mL of 10 mg/mL twice daily is recommended. Individualized therapy is of great importance.
It is further recommended, if 4 mL twice daily of 10 mg/mL does not lead to a clinically satisfactory response, other antihypertensive agents should be added, rather than increase the dose of LASIX ORAL SOLUTION. Pediatrics LASIX ORAL SOLUTION therapy should be instituted in the hospital, in carefully selected patients, under close observation with frequent monitoring of serum electrolytes.
0 mg/kg body weight. The total daily dose (given in divided doses of 6 to 12 hours apart) should not exceed 2 mg/kg orally. In the newborn and in premature babies, the daily dose should not exceed 1 mg/kg. An intermittent dosage schedule should be adopted as soon as possible using th e minimum effective dose at the longest possible intervals.
Particular caution with regard to potassium levels is always desirable when LASIX ORAL SOLUTION is used in infants and children. 5 Missed dose In case of a missed dose, patients may not notice any symptoms of the condition for which they are being treated for.
However, please advise your patients to take the missed dose as soon as possible. And if it is almost time for their next dose, skip the missed dose and take the dose which is due as per the regular dosing schedule. Do not double dose.
5 OVERDOSAGE Symptoms Dehydration, electrolyte depletion and hypotension may be caused by overdosage or accidental ingestion. In cirrhotic patients, overdosage might precipitate hepatic coma. g. hypovolemia, dehydration, hemoconcentration, cardiac arrhythmias (including A-V block and ventricular fibrillation).
Symptoms of these disturbances include severe hypotension (progressing to shock), acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion. Treatment LASIX ORAL SOLUTION (furosemide) Page 7 of 40 The drug should be discontinued and appropriate corrective treatment applied: replacement of excessive fluid and electrolyte losses; serum electrolytes, carbon dioxide level and blood pressure should be determined frequently.
Adequate drainage must be assured in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy). No specific antidote to furosemide is known. g. activated charcoal). For management of a suspected drug overdose, contact your regional poison control centre.
6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING Table 1 – Dosage Forms, Strengths, Composition and Packaging Route of Administration Dosage Form / Strength / Composition Non-medicinal Ingredients Oral Solution 10 mg/mL Alcohol, butylated hydroxyanisol, butylated hydroxytoluene, glycerine, methylparaben, natural orange flavour, polysorbate 80, potassium sorbate, purified water, sodium hydroxide and sorbitol.
LASIX ORAL SOLUTION Clear, slightly yellowish liquid, with an orange odour, containing 10 mg/mL furosemide. Available in bottles of 120 mL. 7 WARNINGS AND PRECAUTIONS General All patients receiving LASIX ORAL SOLUTION therapy should be observed for signs and symptoms of fluid or electrolyte imbalance, hyponatremia, hypochloremic alkalosis, hypovolemia, hypomagnesemia, or hypocalcemia: dryness of the mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, […]