JAMP INDAPAMIDE

25 mg tablet per day taken in the morning as a single dose. 5 mg as a single dose taken in the morning. If the antihypertensive response to JAMP Indapamide (indapamide) is insufficient, an increase in dosage is not recommended (see Warnings).

Instead, a non-diuretic antihypertensive agent should be added to the drug regimen. Alternatively, if in the opinion of the physician, an important diuretic effect is desirable for the patient's control, a different diuretic which allows for dose titration could be tried instead of indapamide.

83 g/mol Chemical Name 4-chloro-N-[2-methyl-1-indolinyl]-3-sulfamoylbenzamide Description A white or almost white powder, practically insoluble in water, soluble in ethanol (96 per cent). 25 mg, and non-medicinal ingredients: Corn starch, D&C yellow no.

10 aluminum lake, FD&C yellow no. 6, hypromellose, lactose monohydrate, macrogol, magnesium stearate, microcrystalline cellulose, polydextrose, povidone, sodium starch glycolate, talc, titanium dioxide, and triacetin. 5 mg, and non-medicinal ingredients: Corn starch, FD&C blue no.

2, FD&C red no. 40, hypromellose, lactose monohydrate, macrogol, magnesium stearate, microcrystalline cellulose, polydextrose, povidone, sodium starch glycolate, talc, titanium dioxide, and triacetin. Stability and Storage Recommendations Store between 15-30C.

Protect from light. Keep out of reach and sight of children. 25 mg are available in bottles of 100 tablets. 25” on the other side. 5 mg are available in bottles of 100 tablets. 5” on the other side. PHARMACOLOGY Indapamide is a non-thiazide sulfonamide derivative with an indole ring, possessing antihypertensive and diuretic properties.

Antihypertensive Action In normal rats, cats and dogs, intravenous administration of 30 mcg to 30 mg/kg failed to change blood pressure or heart rate. No change in cardiac output, heart rate, peripheral or pulmonary resistance was seen.

In rats, oral doses of up to 100 mg/kg did not change blood pressure over a 96-hour measurement period. , of indapamide elicited antihypertensive activity as follows: • in desoxycorticosterone acetate (DOCA)/saline, hypertensive rats with unilateral nephrectomy, a single dose of 10 mg/kg indapamide produced a maximal fall in systolic blood pressure of 25 mmHg after 24 hours and the antihypertensive action lasted for 72 hours.

• similar results were observed in DOCA/saline rats without nephrectomy. • higher doses up to 100 mg/kg produced only small increases in activity but the blood pressure reduction continued for longer than 1 day. Following repeated oral administration of indapamide (1 mg/kg) or trichlormethiazide (3 mg/kg) to DOCA/saline nephrectomized rats for 14 days, mean systolic blood pressure fell more with indapamide (33 mmHg) than with trichlormethiazide (23 mmHg).